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SH2D4A SH2 domain containing 4A [ Homo sapiens (human) ]

Gene ID: 63898, updated on 5-Jul-2025
Official Symbol
SH2D4Aprovided by HGNC
Official Full Name
SH2 domain containing 4Aprovided by HGNC
Primary source
HGNC:HGNC:26102
See related
Ensembl:ENSG00000104611 MIM:614968; AllianceGenome:HGNC:26102
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SH2A; PPP1R38
Summary
Enables phosphatase binding activity. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in ovary (RPKM 11.6), stomach (RPKM 9.2) and 22 other tissues See more
Orthologs
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See SH2D4A in Genome Data Viewer
Location:
8p21.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (19313693..19396218)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (19578579..19661102)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (19171204..19253729)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379300 Neighboring gene uncharacterized LOC105379306 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:19230007-19230168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:19263473-19263973 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:19262972-19263472 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27057 Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:19394183-19395382 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:19435762-19436961 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:19497293-19497837 Neighboring gene uncharacterized LOC124901900 Neighboring gene CSGALNACT1 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:19522068-19523267 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:19536806-19537406

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. SH2D4A inhibits esophageal squamous cell carcinoma progression through FAK/PI3K/AKT signaling pathway. Shi H, et al. Cell Signal, 2024 Feb. PMID 38043670
  2. SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer. Matsumoto T, et al. Br J Cancer, 2022 Apr. PMID 34893760, Free PMC Article
  3. [A novel member of SH(2) signaling protein family: cloning and characterization of SH(2)A gene]. Dai S, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2002 Dec. PMID 12476414
  4. SH2D4A is frequently downregulated in hepatocellular carcinoma and cirrhotic nodules. Quagliata L, et al. Eur J Cancer, 2014 Mar. PMID 24315626
  5. Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin-6 signaling in hepatocellular carcinoma. Ploeger C, et al. Hepatology, 2016 Sep. PMID 27311882, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SH2D4A inhibits esophageal squamous cell carcinoma progression through FAK/PI3K/AKT signaling pathway.
    Title: SH2D4A inhibits esophageal squamous cell carcinoma progression through FAK/PI3K/AKT signaling pathway.
  2. SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer.
    Title: SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer.
  3. The chromosome 8p tumor suppressor genes SORBS3 and SH2D4A are physically and functionally linked and provide a molecular mechanism of inhibiting STAT3-mediated IL-6 signaling in hepatocellular carcinoma cells.
    Title: Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin-6 signaling in hepatocellular carcinoma.
  4. New evidence for SH2D4A involvement in hepatocellular carcinoma pathogenesis demonstrating for the first time its deregulation in cirrhotic nodules.
    Title: SH2D4A is frequently downregulated in hepatocellular carcinoma and cirrhotic nodules.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  6. SH2D4A inhibited cell proliferation by suppression of the ERalpha/PLC-gamma/PKC signaling pathway.
    Title: SH2D4A regulates cell proliferation via the ERalpha/PLC-gamma/PKC pathway.
  7. SH2D4A is dispensable for TCR signal transduction in T cells
    Title: Genetic analysis of SH2D4A, a novel adapter protein related to T cell-specific adapter and adapter protein in lymphocytes of unknown function, reveals a redundant function in T cells.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
EBI GWAS Catalog
Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ20967

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
Preferred Names
SH2 domain-containing protein 4A
Names
protein SH(2)A
protein phosphatase 1 regulatory subunit 38

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001174159.2 → NP_001167630.1  SH2 domain-containing protein 4A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK024799, BC082982, CA418381
    Consensus CDS
    CCDS6009.1
    UniProtKB/Swiss-Prot
    B4DDR1, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H788, Q9H7F7
    Related
    ENSP00000428684.1, ENST00000519207.5
    Conserved Domains (1) summary
    cd10350
    Location:339 → 442
    SH2_SH2D4A; Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A)

  2. NM_001174160.2 → NP_001167631.1  SH2 domain-containing protein 4A isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AK024799, AK293301, CA418381, DA952240
    Consensus CDS
    CCDS55206.1
    UniProtKB/Swiss-Prot
    Q9H788
    Related
    ENSP00000429482.1, ENST00000518040.5
    Conserved Domains (1) summary
    cd10350
    Location:294 → 397
    SH2_SH2D4A; Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A)

  3. NM_001363110.2 → NP_001350039.1  SH2 domain-containing protein 4A isoform c

    Status: VALIDATED

    Source sequence(s)
    AK024799, BC082982, CA418381, DA952240, DB183296
    Conserved Domains (2) summary
    cd10350
    Location:312 → 415
    SH2_SH2D4A; Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A)
    cl26511
    Location:99 → 251
    Neuromodulin_N; Gap junction protein N-terminal region

  4. NM_001363111.2 → NP_001350040.1  SH2 domain-containing protein 4A isoform c

    Status: VALIDATED

    Source sequence(s)
    AK024799, BC082982, CA418381, DB183296
    Conserved Domains (2) summary
    cd10350
    Location:312 → 415
    SH2_SH2D4A; Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A)
    cl26511
    Location:99 → 251
    Neuromodulin_N; Gap junction protein N-terminal region

  5. NM_022071.4 → NP_071354.2  SH2 domain-containing protein 4A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK024799, BC082982, CA418381, DA952240
    Consensus CDS
    CCDS6009.1
    UniProtKB/Swiss-Prot
    B4DDR1, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H788, Q9H7F7
    Related
    ENSP00000265807.3, ENST00000265807.8
    Conserved Domains (1) summary
    cd10350
    Location:339 → 442
    SH2_SH2D4A; Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A)

RNA

  1. NR_156444.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068880, CA418381, DA952240

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    19313693..19396218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422080.1 → XP_047278036.1  SH2 domain-containing protein 4A isoform X2

  2. XM_047422079.1 → XP_047278035.1  SH2 domain-containing protein 4A isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    19578579..19661102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360966.1 → XP_054216941.1  SH2 domain-containing protein 4A isoform X2

  2. XM_054360965.1 → XP_054216940.1  SH2 domain-containing protein 4A isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H788.1 GenPept UniProtKB/Swiss-Prot:Q9H788

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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