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SH2D4A SH2 domain containing 4A [ Homo sapiens (human) ]

Gene ID: 63898, updated on 5-Jul-2025
Official Symbol
SH2D4Aprovided by HGNC
Official Full Name
SH2 domain containing 4Aprovided by HGNC
Primary source
HGNC:HGNC:26102
See related
Ensembl:ENSG00000104611 MIM:614968; AllianceGenome:HGNC:26102
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SH2A; PPP1R38
Summary
Enables phosphatase binding activity. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in ovary (RPKM 11.6), stomach (RPKM 9.2) and 22 other tissues See more
Orthologs
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See SH2D4A in Genome Data Viewer
Location:
8p21.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (19313693..19396218)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (19578579..19661102)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (19171204..19253729)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379300 Neighboring gene uncharacterized LOC105379306 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:19230007-19230168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:19263473-19263973 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:19262972-19263472 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27057 Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:19394183-19395382 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:19435762-19436961 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:19497293-19497837 Neighboring gene uncharacterized LOC124901900 Neighboring gene CSGALNACT1 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:19522068-19523267 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:19536806-19537406

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
EBI GWAS Catalog
Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ20967

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
Preferred Names
SH2 domain-containing protein 4A
Names
protein SH(2)A
protein phosphatase 1 regulatory subunit 38

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001174159.2NP_001167630.1  SH2 domain-containing protein 4A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK024799, BC082982, CA418381
    Consensus CDS
    CCDS6009.1
    UniProtKB/Swiss-Prot
    B4DDR1, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H788, Q9H7F7
    Related
    ENSP00000428684.1, ENST00000519207.5
    Conserved Domains (1) summary
    cd10350
    Location:339442
    SH2_SH2D4A; Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A)
  2. NM_001174160.2NP_001167631.1  SH2 domain-containing protein 4A isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AK024799, AK293301, CA418381, DA952240
    Consensus CDS
    CCDS55206.1
    UniProtKB/Swiss-Prot
    Q9H788
    Related
    ENSP00000429482.1, ENST00000518040.5
    Conserved Domains (1) summary
    cd10350
    Location:294397
    SH2_SH2D4A; Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A)
  3. NM_001363110.2NP_001350039.1  SH2 domain-containing protein 4A isoform c

    Status: VALIDATED

    Source sequence(s)
    AK024799, BC082982, CA418381, DA952240, DB183296
    Conserved Domains (2) summary
    cd10350
    Location:312415
    SH2_SH2D4A; Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A)
    cl26511
    Location:99251
    Neuromodulin_N; Gap junction protein N-terminal region
  4. NM_001363111.2NP_001350040.1  SH2 domain-containing protein 4A isoform c

    Status: VALIDATED

    Source sequence(s)
    AK024799, BC082982, CA418381, DB183296
    Conserved Domains (2) summary
    cd10350
    Location:312415
    SH2_SH2D4A; Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A)
    cl26511
    Location:99251
    Neuromodulin_N; Gap junction protein N-terminal region
  5. NM_022071.4NP_071354.2  SH2 domain-containing protein 4A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK024799, BC082982, CA418381, DA952240
    Consensus CDS
    CCDS6009.1
    UniProtKB/Swiss-Prot
    B4DDR1, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H788, Q9H7F7
    Related
    ENSP00000265807.3, ENST00000265807.8
    Conserved Domains (1) summary
    cd10350
    Location:339442
    SH2_SH2D4A; Src homology 2 domain found in the SH2 domain containing protein 4A (SH2D4A)

RNA

  1. NR_156444.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068880, CA418381, DA952240

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    19313693..19396218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422080.1XP_047278036.1  SH2 domain-containing protein 4A isoform X2

  2. XM_047422079.1XP_047278035.1  SH2 domain-containing protein 4A isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    19578579..19661102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360966.1XP_054216941.1  SH2 domain-containing protein 4A isoform X2

  2. XM_054360965.1XP_054216940.1  SH2 domain-containing protein 4A isoform X1