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UBE2O ubiquitin conjugating enzyme E2 O [ Homo sapiens (human) ]

Gene ID: 63893, updated on 21-Dec-2019

Summary

Official Symbol
UBE2Oprovided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 Oprovided by HGNC
Primary source
HGNC:HGNC:29554
See related
Ensembl:ENSG00000175931 MIM:617649
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E2-230K
Expression
Ubiquitous expression in brain (RPKM 12.9), testis (RPKM 11.1) and 25 other tissues See more
Orthologs

Genomic context

See UBE2O in Genome Data Viewer
Location:
17q25.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (76389456..76453234, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74385613..74449288, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene phosphoribosyl pyrophosphate synthetase associated protein 1 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 43 Neighboring gene sphingosine kinase 1 Neighboring gene ribosomal protein L7 pseudogene 49 Neighboring gene aralkylamine N-acetyltransferase Neighboring gene rhomboid 5 homolog 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat is identified to have a physical interaction with ubiquitin-conjugating enzyme E2O (UBE2O) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12878, KIAA1734

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
cysteine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
protein K63-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein monoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
(E3-independent) E2 ubiquitin-conjugating enzyme
Names
E2/E3 hybrid ubiquitin-protein ligase UBE2O
ubiquitin carrier protein O
ubiquitin conjugating enzyme E2O
ubiquitin-conjugating enzyme E2 of 230 kDa
ubiquitin-conjugating enzyme E2-230K
ubiquitin-protein ligase O
NP_071349.3
XP_005257624.1
XP_016880424.1
XP_024306633.1
XP_024306634.1
XP_024306635.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022066.4NP_071349.3  (E3-independent) E2 ubiquitin-conjugating enzyme

    See identical proteins and their annotated locations for NP_071349.3

    Status: VALIDATED

    Source sequence(s)
    AB051521, AC090699, BC025977, DA092358
    Consensus CDS
    CCDS32742.1
    UniProtKB/Swiss-Prot
    Q9C0C9
    Related
    ENSP00000323687.6, ENST00000319380.12
    Conserved Domains (1) summary
    cd00195
    Location:9581108
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    76389456..76453234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450866.1XP_024306634.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X2

    Conserved Domains (1) summary
    cd00195
    Location:9941144
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. XM_024450867.1XP_024306635.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X3

    Conserved Domains (1) summary
    cd00195
    Location:9701120
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  3. XM_024450865.1XP_024306633.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X1

    Conserved Domains (1) summary
    cd00195
    Location:9951145
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  4. XM_017024935.1XP_016880424.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X5

  5. XM_005257567.1XP_005257624.1  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X4

    See identical proteins and their annotated locations for XP_005257624.1

    Conserved Domains (1) summary
    cd00195
    Location:9591109
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
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