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Stc2 stanniocalcin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 63878, updated on 12-Jan-2022

Summary

Official Symbol
Stc2provided by RGD
Official Full Name
stanniocalcin 2provided by RGD
Primary source
RGD:621777
See related
Ensembl:ENSRNOG00000020729
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable enzyme binding activity; heme binding activity; and protein homodimerization activity. Involved in several processes, including decidualization; embryo implantation; and response to vitamin D. Acts upstream of or within cellular calcium ion homeostasis. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and perinuclear region of cytoplasm. Predicted to be active in extracellular space. Orthologous to human STC2 (stanniocalcin 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Spleen (RPKM 71.6), Heart (RPKM 68.1) and 7 other tissues See more
Orthologs
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Genomic context

See Stc2 in Genome Data Viewer
Location:
10q12
Exon count:
4
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (16251046..16260815)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (16542909..16552675)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551820 Neighboring gene uncharacterized LOC120095058 Neighboring gene NK2 homeobox 5 Neighboring gene BCL2 interacting protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in decidualization IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in embryo implantation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of hormone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of store-operated calcium entry ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to vitamin D IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
stanniocalcin-2
Names
STC-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022230.2NP_071566.1  stanniocalcin-2 precursor

    See identical proteins and their annotated locations for NP_071566.1

    Status: PROVISIONAL

    Source sequence(s)
    AB030707
    UniProtKB/Swiss-Prot
    Q9R0K8
    Related
    ENSRNOP00000028146.1, ENSRNOT00000028146.4
    Conserved Domains (1) summary
    pfam03298
    Location:12213
    Stanniocalcin; Stanniocalcin family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    16251046..16260815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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