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ABHD4 abhydrolase domain containing 4, N-acyl phospholipase B [ Homo sapiens (human) ]

Gene ID: 63874, updated on 8-Jul-2021

Summary

Official Symbol
ABHD4provided by HGNC
Official Full Name
abhydrolase domain containing 4, N-acyl phospholipase Bprovided by HGNC
Primary source
HGNC:HGNC:20154
See related
Ensembl:ENSG00000100439
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ABH4
Expression
Ubiquitous expression in testis (RPKM 27.9), gall bladder (RPKM 15.6) and 25 other tissues See more
Orthologs
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Genomic context

See ABHD4 in Genome Data Viewer
Location:
14q11.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (22598298..22612963)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23067147..23081265)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370399 Neighboring gene defender against cell death 1 Neighboring gene olfactory receptor family 6 subfamily J member 1 Neighboring gene uncharacterized LOC107984651

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12816

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity TAS
Traceable Author Statement
more info
 
enables lysophosphatidic acid acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lysophospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in N-acylphosphatidylethanolamine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
(Lyso)-N-acylphosphatidylethanolamine lipase
Names
abhydrolase domain-containing protein 4
alpha/beta hydrolase domain-containing protein 4
alpha/beta-hydrolase 4
lyso-N-acylphosphatidylethanolamine lipase
protein ABHD4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001392009.1NP_001378938.1  (Lyso)-N-acylphosphatidylethanolamine lipase isoform b

    Status: VALIDATED

    Source sequence(s)
    AC243965
    Conserved Domains (1) summary
    PLN02894
    Location:32314
    PLN02894; hydrolase, alpha/beta fold family protein
  2. NM_022060.3NP_071343.2  (Lyso)-N-acylphosphatidylethanolamine lipase isoform a

    See identical proteins and their annotated locations for NP_071343.2

    Status: VALIDATED

    Source sequence(s)
    AC243965
    Consensus CDS
    CCDS9572.1
    UniProtKB/Swiss-Prot
    Q8TB40
    Related
    ENSP00000414558.2, ENST00000428304.6
    Conserved Domains (1) summary
    PLN02894
    Location:8338
    PLN02894; hydrolase, alpha/beta fold family protein

RNA

  1. NR_171624.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC243965
  2. NR_171625.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC243965
  3. NR_171626.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC243965

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    22598298..22612963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001750499.1 RNA Sequence

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