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ABHD4 abhydrolase domain containing 4, N-acyl phospholipase B [ Homo sapiens (human) ]

Gene ID: 63874, updated on 22-Jan-2020

Summary

Official Symbol
ABHD4provided by HGNC
Official Full Name
abhydrolase domain containing 4, N-acyl phospholipase Bprovided by HGNC
Primary source
HGNC:HGNC:20154
See related
Ensembl:ENSG00000100439
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ABH4
Expression
Ubiquitous expression in testis (RPKM 27.9), gall bladder (RPKM 15.6) and 25 other tissues See more
Orthologs

Genomic context

See ABHD4 in Genome Data Viewer
Location:
14q11.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (22598238..22612864)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23067147..23081265)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370399 Neighboring gene long intergenic non-protein coding RNA 2332 Neighboring gene defender against cell death 1 Neighboring gene olfactory receptor family 6 subfamily J member 1 (gene/pseudogene) Neighboring gene uncharacterized LOC107984651

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12816

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hydrolase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
N-acylphosphatidylethanolamine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
(Lyso)-N-acylphosphatidylethanolamine lipase
Names
abhydrolase domain containing 4
abhydrolase domain-containing protein 4
alpha/beta hydrolase domain-containing protein 4
alpha/beta-hydrolase 4
lyso-N-acylphosphatidylethanolamine lipase
protein ABHD4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022060.2NP_071343.2  (Lyso)-N-acylphosphatidylethanolamine lipase

    See identical proteins and their annotated locations for NP_071343.2

    Status: VALIDATED

    Source sequence(s)
    AK022878, AK024790, BC024779
    Consensus CDS
    CCDS9572.1
    UniProtKB/Swiss-Prot
    Q8TB40
    Related
    ENSP00000414558.2, ENST00000428304.6
    Conserved Domains (1) summary
    cl26327
    Location:8338
    Abhydrolase_1; alpha/beta hydrolase fold

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    22598238..22612864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267986.4XP_005268043.1  (Lyso)-N-acylphosphatidylethanolamine lipase isoform X1

    See identical proteins and their annotated locations for XP_005268043.1

    Conserved Domains (2) summary
    COG0596
    Location:43317
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam12695
    Location:46163
    Abhydrolase_5; Alpha/beta hydrolase family

RNA

  1. XR_001750499.1 RNA Sequence

  2. XR_245712.4 RNA Sequence

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