U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hspd1 heat shock protein family D (Hsp60) member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 63868, updated on 22-Jan-2023

Summary

Official Symbol
Hspd1provided by RGD
Official Full Name
heat shock protein family D (Hsp60) member 1provided by RGD
Primary source
RGD:621314
See related
Ensembl:ENSRNOG00000014525 AllianceGenome:RGD:621314
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hsp60; Hspd1-30p
Summary
Enables modification-dependent protein binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of cytokine production; and response to ischemia. Located in several cellular components, including mitochondrial crista; peroxisomal matrix; and zymogen granule. Used to study Alzheimer's disease and low tension glaucoma. Biomarker of several diseases, including artery disease (multiple); hydrocephalus; hyperglycemia; pulmonary fibrosis; and varicocele. Human ortholog(s) of this gene implicated in artery disease (multiple); autistic disorder; glucose intolerance; hereditary spastic paraplegia (multiple); and hypomyelinating leukodystrophy 4. Orthologous to human HSPD1 (heat shock protein family D (Hsp60) member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 7685.9), Kidney (RPKM 1832.5) and 7 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Hspd1 in Genome Data Viewer
Location:
9q31
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (56579195..56590011, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (61680529..61691202, complement)

Chromosome 9 - NC_051344.1Genomic Context describing neighboring genes Neighboring gene splicing factor 3b, subunit 1 Neighboring gene coenzyme Q10B Neighboring gene heat shock protein family E (Hsp10) member 1 Neighboring gene glycine cleavage system H protein, mitochondrial pseudogene Neighboring gene MOB family member 4, phocein Neighboring gene raftlin family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables apolipoprotein A-I binding ISO
Inferred from Sequence Orthology
more info
 
enables apolipoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables high-density lipoprotein particle binding ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables modification-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in 'de novo' protein folding IC
Inferred by Curator
more info
PubMed 
involved_in B cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in MyD88-dependent toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in adhesion of symbiont to host ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic mitochondrial changes IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in apoptotic mitochondrial changes IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in biological process involved in interaction with symbiont ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to interleukin-7 ISO
Inferred from Sequence Orthology
more info
 
involved_in isotype switching to IgG isotypes ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process in bone marrow cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell mediated immune response to tumor cell ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interferon-alpha production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of type II interferon production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein import into mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein refolding ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ATP IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to cocaine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to cold ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ischemia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to unfolded protein ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi cisterna IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
located_in coated vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
part_of lipopolysaccharide receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in migrasome ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial crista IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisomal matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 
located_in sperm midpiece ISO
Inferred from Sequence Orthology
more info
 
located_in sperm plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in zymogen granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
60 kDa heat shock protein, mitochondrial
Names
60 kDa chaperonin
CPN60
HSP-60
HSP-65
chaperonin 60
heat shock 60kD protein 1 (chaperonin)
heat shock 60kDa protein 1
heat shock protein 1 (chaperonin)
heat shock protein 60 (liver)
heat shock protein family D member 1
mitochondrial matrix protein P1
NP_071565.2
XP_006244994.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022229.2NP_071565.2  60 kDa heat shock protein, mitochondrial

    See identical proteins and their annotated locations for NP_071565.2

    Status: PROVISIONAL

    Source sequence(s)
    BC086507
    UniProtKB/Swiss-Prot
    P63039, P97602
    UniProtKB/TrEMBL
    A0A482IDN3
    Related
    ENSRNOP00000063666.2, ENSRNOT00000066589.3
    Conserved Domains (1) summary
    cd03344
    Location:28548
    GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051344.1 Reference mRatBN7.2 Primary Assembly

    Range
    56579195..56590011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244932.3XP_006244994.1  60 kDa heat shock protein, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006244994.1

    UniProtKB/Swiss-Prot
    P63039, P97602
    UniProtKB/TrEMBL
    A0A482IDN3
    Conserved Domains (1) summary
    cd03344
    Location:28548
    GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...