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BCAN brevican [ Homo sapiens (human) ]

Gene ID: 63827, updated on 1-Jun-2020

Summary

Official Symbol
BCANprovided by HGNC
Official Full Name
brevicanprovided by HGNC
Primary source
HGNC:HGNC:23059
See related
Ensembl:ENSG00000132692 MIM:600347
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BEHAB; CSPG7
Summary
This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Expression
Restricted expression toward brain (RPKM 121.6) See more
Orthologs

Genomic context

See BCAN in Genome Data Viewer
Location:
1q23.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (156642117..156659528)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156611740..156629324)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene G-patch domain containing 4 Neighboring gene NAD(P)HX epimerase Neighboring gene hyaluronan and proteoglycan link protein 2 Neighboring gene uncharacterized LOC101928177 Neighboring gene uncharacterized LOC105371453 Neighboring gene VISTA enhancer hs1891 Neighboring gene nestin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC13038

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
hyaluronic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chondroitin sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
chondroitin sulfate catabolic process TAS
Traceable Author Statement
more info
 
dermatan sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
skeletal system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse maturation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi lumen TAS
Traceable Author Statement
more info
 
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
lysosomal lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
brevican core protein
Names
brain-enriched hyaluronan-binding protein
chondroitin sulfate proteoglycan 7
chondroitin sulfate proteoglycan BEHAB

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030013.1 RefSeqGene

    Range
    5170..22581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021948.5NP_068767.3  brevican core protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_068767.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL365181, AL590666, AY358372, BC027971
    Consensus CDS
    CCDS1149.1
    UniProtKB/Swiss-Prot
    Q96GW7
    Related
    ENSP00000331210.4, ENST00000329117.10
    Conserved Domains (8) summary
    cd00033
    Location:815872
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00410
    Location:44154
    IG_like; Immunoglobulin like
    cd03517
    Location:157251
    Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
    cd03520
    Location:258353
    Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
    pfam00008
    Location:650679
    EGF; EGF-like domain
    pfam08688
    Location:483558
    ASD1; Apx/Shroom domain ASD1
    cl02432
    Location:688811
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cl11960
    Location:49158
    Ig; Immunoglobulin domain
  2. NM_198427.2NP_940819.1  brevican core protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_940819.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, and coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF229053, AW298823, AY358372
    Consensus CDS
    CCDS1150.1
    UniProtKB/Swiss-Prot
    Q96GW7
    Related
    ENSP00000354925.5, ENST00000361588.5
    Conserved Domains (4) summary
    smart00410
    Location:44154
    IG_like; Immunoglobulin like
    cd03517
    Location:157251
    Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
    cd03520
    Location:258353
    Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
    cl11960
    Location:49158
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    156642117..156659528
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509866.1XP_011508168.1  brevican core protein isoform X2

    See identical proteins and their annotated locations for XP_011508168.1

    UniProtKB/Swiss-Prot
    Q96GW7
    Conserved Domains (8) summary
    cd00033
    Location:815872
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00410
    Location:44154
    IG_like; Immunoglobulin like
    cd03517
    Location:157251
    Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
    cd03520
    Location:258353
    Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
    pfam00008
    Location:650679
    EGF; EGF-like domain
    pfam08688
    Location:483558
    ASD1; Apx/Shroom domain ASD1
    cl02432
    Location:688811
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cl11960
    Location:49158
    Ig; Immunoglobulin domain
  2. XM_017002047.1XP_016857536.1  brevican core protein isoform X1

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