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BIK BCL2 interacting killer [ Homo sapiens (human) ]

Gene ID: 638, updated on 25-Nov-2021

Summary

Official Symbol
BIKprovided by HGNC
Official Full Name
BCL2 interacting killerprovided by HGNC
Primary source
HGNC:HGNC:1051
See related
Ensembl:ENSG00000100290 MIM:603392
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BP4; NBK; BIP1
Summary
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]
Expression
Biased expression in stomach (RPKM 6.4), colon (RPKM 5.6) and 13 other tissues See more
Orthologs
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Genomic context

See BIK in Genome Data Viewer
Location:
22q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (43110750..43129712)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (43506756..43525718)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S25 pseudogene 10 Neighboring gene Sharpr-MPRA regulatory region 7153 Neighboring gene malonyl-CoA-acyl carrier protein transacylase Neighboring gene translocator protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies new prostate cancer susceptibility loci.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Bcl-2 family protein complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
bcl-2-interacting killer
Names
BCL2-interacting killer (apoptosis-inducing)
apoptosis inducer NBK
apoptosis-inducing NBK
natural born killer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197.5NP_001188.1  bcl-2-interacting killer

    See identical proteins and their annotated locations for NP_001188.1

    Status: REVIEWED

    Source sequence(s)
    BC001599, BP329261, U34584
    Consensus CDS
    CCDS14044.1
    UniProtKB/Swiss-Prot
    Q13323
    UniProtKB/TrEMBL
    A0A024R4X6
    Related
    ENSP00000216115.2, ENST00000216115.3
    Conserved Domains (1) summary
    pfam12201
    Location:1136
    bcl-2I13; Bcl2-interacting killer, BH3-domain containing

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    43110750..43129712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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