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BIK BCL2 interacting killer [ Homo sapiens (human) ]

Gene ID: 638, updated on 12-May-2019

Summary

Official Symbol
BIKprovided by HGNC
Official Full Name
BCL2 interacting killerprovided by HGNC
Primary source
HGNC:HGNC:1051
See related
Ensembl:ENSG00000100290 MIM:603392
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BP4; NBK; BIP1
Summary
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]
Expression
Biased expression in stomach (RPKM 6.4), colon (RPKM 5.6) and 13 other tissues See more
Orthologs

Genomic context

See BIK in Genome Data Viewer
Location:
22q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (43110748..43129712)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (43506754..43525718)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506679 Neighboring gene tubulin tyrosine ligase like 1 Neighboring gene ribosomal protein S25 pseudogene 10 Neighboring gene malonyl-CoA-acyl carrier protein transacylase Neighboring gene translocator protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Apoptosis Modulation and Signaling, organism-specific biosystem (from WikiPathways)
    Apoptosis Modulation and Signaling, organism-specific biosystemApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrin...
  • DNA Damage Response (only ATM dependent), organism-specific biosystem (from WikiPathways)
    DNA Damage Response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
  • Endocrine resistance, organism-specific biosystem (from KEGG)
    Endocrine resistance, organism-specific biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
  • Endocrine resistance, conserved biosystem (from KEGG)
    Endocrine resistance, conserved biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic mitochondrial changes IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
male gonad development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endomembrane system IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
bcl-2-interacting killer
Names
BCL2-interacting killer (apoptosis-inducing)
apoptosis inducer NBK
apoptosis-inducing NBK
natural born killer

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197.5NP_001188.1  bcl-2-interacting killer

    See identical proteins and their annotated locations for NP_001188.1

    Status: REVIEWED

    Source sequence(s)
    BC001599, BP329261, U34584
    Consensus CDS
    CCDS14044.1
    UniProtKB/Swiss-Prot
    Q13323
    UniProtKB/TrEMBL
    A0A024R4X6
    Related
    ENSP00000216115.2, ENST00000216115.3
    Conserved Domains (1) summary
    pfam12201
    Location:1136
    bcl-2I13; Bcl2-interacting killer, BH3-domain containing

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    43110748..43129712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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