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BID BH3 interacting domain death agonist [ Homo sapiens (human) ]

Gene ID: 637, updated on 27-Feb-2020

Summary

Official Symbol
BIDprovided by HGNC
Official Full Name
BH3 interacting domain death agonistprovided by HGNC
Primary source
HGNC:HGNC:1050
See related
Ensembl:ENSG00000015475 MIM:601997
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FP497
Summary
This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jan 2020]
Expression
Ubiquitous expression in bone marrow (RPKM 13.8), brain (RPKM 9.4) and 24 other tissues See more
Orthologs

Genomic context

See BID in Genome Data Viewer
Location:
22q11.21
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (17734140..17774665, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (18216906..18257431, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 18 Neighboring gene ATPase H+ transporting V1 subunit E1 Neighboring gene BCL2 like 13 Neighboring gene microRNA 3198-1 Neighboring gene nonconserved acetylation island sequence 74 enhancer Neighboring gene long intergenic non-protein coding RNA 528

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Caspase 8 proteolytic target protein Bid is cleaved and undergoes mitochondrial translocation in gp120-treated p53 expression neurons PubMed
Tat tat HIV-1 Tat upregulates the expression of BH3 interacting domain death agonist (BID) in Jurkat cells PubMed
tat FasL-induced cleavage of BID/p22 and BCL2 is inhibited in HIV-1 Tat101-expressing Jurkat cells PubMed
Vpr vpr HIV-1 Vpr-mediated apoptosis and mitochondrial depolarization are dependent on BID activation in THP-1 cells PubMed
vpr Inhibition of MEK1,2 impairs HIV-1 Vpr-induced BID cleavage PubMed
vpr HIV-1 Vpr-induced caspase-8 activation causes cleavage of BID to tBID through ERK activation PubMed
vpr Overexpression of BID is induced by HIV-1 Vpr in the transfected 293T cells PubMed
retropepsin gag-pol HIV-1 protease directly cleaves and activates procaspase 8 in T cells which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, and cleavage of DFF and PARP PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC15319, MGC42355

Gene Ontology Provided by GOA

Function Evidence Code Pubs
death receptor binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic mitochondrial changes IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment of protein localization to membrane IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
PubMed 
hepatocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
mitochondrial ATP synthesis coupled electron transport IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane permeabilization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 
neuron apoptotic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fibroblast apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intrinsic apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of protein oligomerization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of release of cytochrome c from mitochondria IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of release of cytochrome c from mitochondria IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of release of cytochrome c from mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein targeting to mitochondrion IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process TAS
Traceable Author Statement
more info
 
regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction in response to DNA damage TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
integral component of mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
BH3-interacting domain death agonist
Names
BH3 interacting domain death agonist Si6 isoform
BID isoform ES(1b)
BID isoform L(2)
BID isoform Si6
Human BID coding sequence
apoptic death agonist
desmocollin type 4
p22 BID

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001196.3NP_001187.1  BH3-interacting domain death agonist isoform 2

    See identical proteins and their annotated locations for NP_001187.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon and uses a downstream in-frame start codon, as compared to variant 1. The encoded isoform 2 thus has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC006285, AK094795, BC036364, BM561391, BM842561
    Consensus CDS
    CCDS13748.1
    UniProtKB/Swiss-Prot
    P55957
    UniProtKB/TrEMBL
    A8ASI8, B3KT21
    Related
    ENSP00000480414.1
    Conserved Domains (1) summary
    pfam06393
    Location:3192
    BID; BH3 interacting domain (BID)
  2. NM_001244567.1NP_001231496.1  BH3-interacting domain death agonist isoform 2

    See identical proteins and their annotated locations for NP_001231496.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' exon and uses a downstream in-frame start codon, as compared to variant 1. The encoded isoform 2 thus has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC006285, AK094795, BC036364, EU678294
    Consensus CDS
    CCDS13748.1
    UniProtKB/Swiss-Prot
    P55957
    UniProtKB/TrEMBL
    A8ASI8, B3KT21
    Related
    ENSP00000449236.1, ENST00000551952.5
    Conserved Domains (1) summary
    pfam06393
    Location:3192
    BID; BH3 interacting domain (BID)
  3. NM_001244569.1NP_001231498.1  BH3-interacting domain death agonist isoform 3

    See identical proteins and their annotated locations for NP_001231498.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate 5' exon and uses a downstream in-frame start codon, as compared to variant 1. The encoded isoform 3 thus has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC006285, AK094795, BC036364, CN277529, DA158889
    Consensus CDS
    CCDS13749.1
    UniProtKB/Swiss-Prot
    P55957
    UniProtKB/TrEMBL
    B2ZP79, B3KT21
    Related
    ENSP00000477773.1, ENST00000614949.4
    Conserved Domains (1) summary
    pfam06393
    Location:196
    BID; BH3 interacting domain (BID)
  4. NM_001244570.1NP_001231499.1  BH3-interacting domain death agonist isoform 3

    See identical proteins and their annotated locations for NP_001231499.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has an alternate 5' exon and uses a downstream in-frame start codon, as compared to variant 1. The encoded isoform 3 thus has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC006285, AK094795, BC036364, DA007047, DA158889
    Consensus CDS
    CCDS13749.1
    UniProtKB/Swiss-Prot
    P55957
    UniProtKB/TrEMBL
    B2ZP79, B3KT21
    Related
    ENSP00000382667.1, ENST00000399765.5
    Conserved Domains (1) summary
    pfam06393
    Location:196
    BID; BH3 interacting domain (BID)
  5. NM_001244572.1NP_001231501.1  BH3-interacting domain death agonist isoform 3

    See identical proteins and their annotated locations for NP_001231501.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks two alternate coding exons compared to variant 1, that causes a frameshift. This variant uses a downstream in-frame start-codon, so the encoded isoform 3 has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC006285, AK094795, BC036364, DA274603, DB167767
    Consensus CDS
    CCDS13749.1
    UniProtKB/Swiss-Prot
    P55957
    UniProtKB/TrEMBL
    B2ZP79, B3KT21
    Related
    ENSP00000483534.1, ENST00000615414.4
    Conserved Domains (1) summary
    pfam06393
    Location:196
    BID; BH3 interacting domain (BID)
  6. NM_197966.2NP_932070.1  BH3-interacting domain death agonist isoform 1

    See identical proteins and their annotated locations for NP_932070.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC006285, AF250233, AK094795, BC036364, DA274603
    Consensus CDS
    CCDS13747.1
    UniProtKB/Swiss-Prot
    P55957
    UniProtKB/TrEMBL
    B3KT21
    Related
    ENSP00000318822.7, ENST00000317361.11
    Conserved Domains (1) summary
    pfam06393
    Location:49238
    BID; BH3 interacting domain (BID)
  7. NM_197967.2NP_932071.1  BH3-interacting domain death agonist isoform 3

    See identical proteins and their annotated locations for NP_932071.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' region and uses a downstream start codon, as compared to variant 1. It encodes isoform 3 which has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC006285, AK094795, BC036364, DA158889
    Consensus CDS
    CCDS13749.1
    UniProtKB/Swiss-Prot
    P55957
    UniProtKB/TrEMBL
    B2ZP79, B3KT21
    Related
    ENSP00000382669.1, ENST00000399767.5
    Conserved Domains (1) summary
    pfam06393
    Location:196
    BID; BH3 interacting domain (BID)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    17734140..17774665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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