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Cntnap5a contactin associated protein-like 5A [ Mus musculus (house mouse) ]

Gene ID: 636808, updated on 30-Apr-2024

Summary

Official Symbol
Cntnap5aprovided by MGI
Official Full Name
contactin associated protein-like 5Aprovided by MGI
Primary source
MGI:MGI:3643623
See related
Ensembl:ENSMUSG00000070695 AllianceGenome:MGI:3643623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Caspr5-1; EG636808
Summary
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in central nervous system. Orthologous to human CNTNAP5 (contactin associated protein family member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 2.7), cortex adult (RPKM 2.4) and 6 other tissues See more
Orthologs
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Genomic context

See Cntnap5a in Genome Data Viewer
Location:
1 E2.3; 1 51.59 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (115612467..116515053)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (115684737..116587323)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01947 Neighboring gene leukotriene A4 hydrolase pseudogene Neighboring gene STARR-seq mESC enhancer starr_01948 Neighboring gene STARR-seq mESC enhancer starr_01949 Neighboring gene STARR-seq mESC enhancer starr_01950 Neighboring gene predicted gene, 50605 Neighboring gene tubulin, beta 2A pseudogene Neighboring gene STARR-seq mESC enhancer starr_01951 Neighboring gene STARR-seq mESC enhancer starr_01952 Neighboring gene STARR-seq mESC enhancer starr_01953 Neighboring gene STARR-seq mESC enhancer starr_01955 Neighboring gene STARR-seq mESC enhancer starr_01956 Neighboring gene STARR-seq mESC enhancer starr_01957 Neighboring gene STARR-seq mESC enhancer starr_01959 Neighboring gene STARR-seq mESC enhancer starr_01960 Neighboring gene STARR-seq mESC enhancer starr_01962 Neighboring gene STARR-seq mESC enhancer starr_01963 Neighboring gene predicted gene, 17777 Neighboring gene predicted gene, 24030

Genomic regions, transcripts, and products

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
contactin-associated protein like 5-1
Names
cell recognition molecule Caspr5-1
cell recognition molecule Caspr5a
contactin-associated protein-like 5a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077425.2NP_001070893.1  contactin-associated protein like 5-1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001070893.1

    Status: VALIDATED

    Source sequence(s)
    AC098737, AC110160, AC122189, AC122812, AC124547, AC124690, AC132403
    Consensus CDS
    CCDS35689.1
    UniProtKB/Swiss-Prot
    Q0V8T9
    Related
    ENSMUSP00000035732.9, ENSMUST00000043725.9
    Conserved Domains (6) summary
    smart00282
    Location:205338
    LamG; Laminin G domain
    cd00054
    Location:960994
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00057
    Location:56173
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd00110
    Location:792936
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:550581
    EGF; EGF-like domain
    pfam02210
    Location:395518
    Laminin_G_2; Laminin G domain
  2. NM_001371013.1NP_001357942.1  contactin-associated protein like 5-1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC098737, AC110160, AC122189, AC122812, AC124547, AC124690, AC132403
    Conserved Domains (6) summary
    smart00282
    Location:205338
    LamG; Laminin G domain
    cd00054
    Location:961995
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00057
    Location:56173
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd00110
    Location:793937
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:551582
    EGF; EGF-like domain
    pfam02210
    Location:396519
    Laminin_G_2; Laminin G domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    115612467..116515053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529774.4XP_006529837.1  contactin-associated protein like 5-1 isoform X1

    Conserved Domains (6) summary
    smart00282
    Location:144277
    LamG; Laminin G domain
    cd00054
    Location:900934
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00057
    Location:2112
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd00110
    Location:732876
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:490521
    EGF; EGF-like domain
    pfam02210
    Location:335458
    Laminin_G_2; Laminin G domain