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CCL23 C-C motif chemokine ligand 23 [ Homo sapiens (human) ]

Gene ID: 6368, updated on 22-Aug-2020

Summary

Official Symbol
CCL23provided by HGNC
Official Full Name
C-C motif chemokine ligand 23provided by HGNC
Primary source
HGNC:HGNC:10622
See related
Ensembl:ENSG00000274736 MIM:602494
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKb8; MIP3; Ckb-8; MIP-3; MPIF-1; SCYA23; Ckb-8-1; hmrp-2a; CK-BETA-8
Summary
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
Expression
Broad expression in appendix (RPKM 3.6), lung (RPKM 2.2) and 15 other tissues See more
Orthologs

Genomic context

See CCL23 in Genome Data Viewer
Location:
17q12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (36013056..36018179, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34340096..34345005, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CCL15-CCL14 readthrough (NMD candidate) Neighboring gene C-C motif chemokine ligand 16 Neighboring gene C-C motif chemokine ligand 14 Neighboring gene uncharacterized LOC107985068 Neighboring gene C-C motif chemokine ligand 15 Neighboring gene uncharacterized LOC105371746 Neighboring gene C-C motif chemokine ligand 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of lung function phenotypes in a founder population.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates the gene expression of CCL23 in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CCR1 chemokine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine activity IDA
Inferred from Direct Assay
more info
PubMed 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cellular calcium ion homeostasis TAS
Traceable Author Statement
more info
PubMed 
cellular response to interferon-gamma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to interleukin-1 IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to tumor necrosis factor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemotaxis TAS
Traceable Author Statement
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lymphocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
monocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
monocyte chemotaxis IC
Inferred by Curator
more info
PubMed 
negative regulation of C-C chemokine binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
C-C motif chemokine 23
Names
C6 beta-chemokine
chemokine (C-C motif) ligand 23
macrophage inflammatory protein 3
myeloid progenitor inhibitory factor 1
small inducible cytokine subfamily A (Cys-Cys), member 23

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029876.2 RefSeqGene

    Range
    4997..9911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005064.6NP_005055.3  C-C motif chemokine 23 isoform CKbeta8-1 precursor

    See identical proteins and their annotated locations for NP_005055.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (CKbeta8-1) represents the longer transcript and encodes the longer isoform (CKbeta8-1).
    Source sequence(s)
    AC244100, BC143310, U58913, U85767
    Consensus CDS
    CCDS11305.1
    UniProtKB/Swiss-Prot
    P55773
    Related
    ENSP00000481357.1, ENST00000615050.2
    Conserved Domains (1) summary
    smart00199
    Location:68126
    SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)
  2. NM_145898.4NP_665905.2  C-C motif chemokine 23 isoform CKbeta8 precursor

    See identical proteins and their annotated locations for NP_665905.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (CKbeta8) uses an alternate, in-frame splice site in the coding region, compared to transcript variant CKbeta8-1. This difference results in a shorter protein (isoform CKbeta8) compared to isoform CKbeta8-1.
    Source sequence(s)
    AC244100, BC093970, U58913, U85767
    Consensus CDS
    CCDS59282.1
    UniProtKB/Swiss-Prot
    P55773
    Related
    ENSP00000484748.1, ENST00000612516.4
    Conserved Domains (1) summary
    smart00199
    Location:51109
    SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    36013056..36018179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_429910.3 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    247626..252537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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