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CCL19 C-C motif chemokine ligand 19 [ Homo sapiens (human) ]

Gene ID: 6363, updated on 8-Nov-2020

Summary

Official Symbol
CCL19provided by HGNC
Official Full Name
C-C motif chemokine ligand 19provided by HGNC
Primary source
HGNC:HGNC:10617
See related
Ensembl:ENSG00000172724 MIM:602227
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ELC; CKb11; MIP3B; MIP-3b; SCYA19
Summary
This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]
Expression
Biased expression in appendix (RPKM 274.6), lymph node (RPKM 208.4) and 5 other tissues See more
Orthologs

Genomic context

See CCL19 in Genome Data Viewer
Location:
9p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (34689570..34691276, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (34689567..34691274, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene interleukin 11 receptor subunit alpha Neighboring gene uncharacterized LOC107987063 Neighboring gene uncharacterized LOC730098 Neighboring gene C-C motif chemokine ligand 27 Neighboring gene C-C motif chemokine ligand 21 Neighboring gene family with sequence similarity 205 member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef impairs the mobility of primary CD4+ lymphocytes and inhibits chemotaxis of primary T cells to CCL19 PubMed
Pr55(Gag) gag The migration capacity of MVA-gag-infected human monocyte-derived dendritic cells is significantly higher in the presence of CCL19 than in the absence of this chemokine PubMed
Tat tat HIV-1 Tat upregulates the expression of chemokine (C-C motif) ligand 19 (CCL19) in human primary T cells PubMed
Vpu vpu HIV-1 Vpu inhibits the chemotactic potential of primary CD4+ T cells to migrate specifically toward CCL19 PubMed
vpu Vpu-mediated downregulation of CCR7 upon viral infection results in an impaired ability of infected primary CD4+ T cells to respond to CCL19 PubMed
capsid gag The migration capacity of PLA-p24-loaded human monocyte-derived dendritic cells is significantly higher in the presence of CCL19 than in the absence of this chemokine PubMed
matrix gag Treatment of plasmacytoid dendritic cells (pDCs) with HIV-1 MA upregulates the expression of CCR7. Coculture with MA and CCL19 induces a dose-dependent migration of pDCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC34433

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CCR chemokine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
CCR10 chemokine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
CCR7 chemokine receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine activity IDA
Inferred from Direct Assay
more info
PubMed 
chemokine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
T cell costimulation ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
cell communication TAS
Traceable Author Statement
more info
PubMed 
cell maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular calcium ion homeostasis TAS
Traceable Author Statement
more info
PubMed 
cellular response to interferon-gamma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to interleukin-1 IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to tumor necrosis factor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
dendritic cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
establishment of T cell polarity IDA
Inferred from Direct Assay
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
immunological synapse formation ISS
Inferred from Sequence or Structural Similarity
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
lymphocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mature conventional dendritic cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
monocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myeloid dendritic cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of dendritic cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of T-helper 1 cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell motility IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of dendritic cell antigen processing and presentation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of dendritic cell dendrite assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of glycoprotein biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-1 beta production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-12 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of receptor-mediated endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell projection assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
response to nitric oxide IDA
Inferred from Direct Assay
more info
PubMed 
response to prostaglandin E IDA
Inferred from Direct Assay
more info
PubMed 
response to virus TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
C-C motif chemokine 19
Names
CC chemokine ligand 19
CK beta-11
EBI1-ligand chemokine
MIP-3-beta
beta chemokine exodus-3
chemokine (C-C motif) ligand 19
epstein-Barr virus-induced molecule 1 ligand chemokine
exodus-3
macrophage inflammatory protein 3-beta
small inducible cytokine subfamily A (Cys-Cys), member 19
small-inducible cytokine A19

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006274.3NP_006265.1  C-C motif chemokine 19 precursor

    See identical proteins and their annotated locations for NP_006265.1

    Status: REVIEWED

    Source sequence(s)
    AL162231
    Consensus CDS
    CCDS6570.1
    UniProtKB/Swiss-Prot
    Q99731
    UniProtKB/TrEMBL
    Q6IBD6
    Related
    ENSP00000308815.2, ENST00000311925.7
    Conserved Domains (1) summary
    cd01119
    Location:2787
    Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    34689570..34691276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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