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CCL14 C-C motif chemokine ligand 14 [ Homo sapiens (human) ]

Gene ID: 6358, updated on 18-Sep-2024

Summary

Official Symbol
CCL14provided by HGNC
Official Full Name
C-C motif chemokine ligand 14provided by HGNC
Primary source
HGNC:HGNC:10612
See related
Ensembl:ENSG00000276409 MIM:601392; AllianceGenome:HGNC:10612
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CC-1; CC-3; CKB1; MCIF; NCC2; SY14; HCC-1; HCC-3; NCC-2; SCYL2; SCYA14; HCC-1(1-74); HCC-1/HCC-3
Summary
This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. [provided by RefSeq, Dec 2009]
Expression
Broad expression in spleen (RPKM 229.5), fat (RPKM 134.4) and 15 other tissues See more
Orthologs
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Genomic context

See CCL14 in Genome Data Viewer
Location:
17q12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (35983288..35986729, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (36931192..36934633, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34310324..34313765, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene lysozyme like 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:34288003-34288221 Neighboring gene Sharpr-MPRA regulatory region 10414 Neighboring gene C-C motif chemokine ligand 16 Neighboring gene CCL15-CCL14 readthrough (NMD candidate) Neighboring gene uncharacterized LOC107985068 Neighboring gene C-C motif chemokine ligand 15 Neighboring gene C-C motif chemokine ligand 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of chemokine (C-C motif) ligand 14 (CCL14) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough CCL15-CCL14

Readthrough gene: CCL15-CCL14, Included gene: CCL15

Clone Names

  • FLJ16015

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables CCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in eosinophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular calcium ion homeostasis TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
C-C motif chemokine 14
Names
chemokine (C-C motif) ligand 14
chemokine CC-1/CC-3
chemokine CC-3
hemofiltrate CC chemokine 1
new CC chemokine 2
small inducible cytokine subfamily A (Cys-Cys), member 14
small-inducible cytokine A14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032962.5NP_116738.1  C-C motif chemokine 14 isoform 2 precursor

    See identical proteins and their annotated locations for NP_116738.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as CCL14b) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AA612866, AC244100, BC045165, BI496964, DA821276
    Consensus CDS
    CCDS45652.1
    UniProtKB/Swiss-Prot
    Q16627
    Related
    ENSP00000479097.1, ENST00000622526.1
    Conserved Domains (1) summary
    smart00199
    Location:48106
    SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)
  2. NM_032963.4NP_116739.1  C-C motif chemokine 14 isoform 1 precursor

    See identical proteins and their annotated locations for NP_116739.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, CCL14a) lacks an alternate in-frame exon in the 5' coding region, compared to variant 2. The resulting isoform (1) lacks an alternate segment near the N-terminus, compared to isoform 2.
    Source sequence(s)
    AC244100, DA821276
    Consensus CDS
    CCDS32624.1
    UniProtKB/Swiss-Prot
    E1P649, E1P650, Q13954, Q16627
    Related
    ENSP00000481023.1, ENST00000618404.5
    Conserved Domains (1) summary
    smart00199
    Location:3290
    SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    35983288..35986729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    217852..221293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    36931192..36934633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004166.4: Suppressed sequence

    Description
    NM_004166.4: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.