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Defa38 defensin, alpha, 38 [ Mus musculus (house mouse) ]

Gene ID: 634825, updated on 13-Oct-2022

Summary

Official Symbol
Defa38provided by MGI
Official Full Name
defensin, alpha, 38provided by MGI
Primary source
MGI:MGI:3709605
See related
Ensembl:ENSMUSG00000061958 AllianceGenome:MGI:3709605
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CRS1C-2; Gm14851
Summary
Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; innate immune response in mucosa; and response to bacterium. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 802.5), small intestine adult (RPKM 378.2) and 1 other tissue See more
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Genomic context

See Defa38 in Genome Data Viewer
Location:
8 A2; 8
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (21584987..21586066, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (21094971..21096050, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene defensin, alpha, 25 Neighboring gene ribosomal protein L21 pseudogene Neighboring gene predicted gene, 24568 Neighboring gene zinc finger, MYM-type 5 pseudogene Neighboring gene defensin, alpha, 30

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response in mucosa IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in azurophil granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
defensin, alpha, 38
Names
alpha-defensin related antimicrobial peptide
cryptdin-related sequence peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177482.2NP_001170953.1  defensin, alpha, 38 precursor

    See identical proteins and their annotated locations for NP_001170953.1

    Status: VALIDATED

    Source sequence(s)
    AC129197
    Consensus CDS
    CCDS52503.1
    UniProtKB/TrEMBL
    Q5ERJ0
    Related
    ENSMUSP00000076665.4, ENSMUST00000077452.4
    Conserved Domains (1) summary
    pfam00879
    Location:1551
    Defensin_propep; Defensin propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    21584987..21586066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)