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SCTR secretin receptor [ Homo sapiens (human) ]

Gene ID: 6344, updated on 4-Jun-2020

Summary

Official Symbol
SCTRprovided by HGNC
Official Full Name
secretin receptorprovided by HGNC
Primary source
HGNC:HGNC:10608
See related
Ensembl:ENSG00000080293 MIM:182098
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SR
Summary
The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq, Jul 2008]
Expression
Biased expression in duodenum (RPKM 6.3), pancreas (RPKM 4.3) and 5 other tissues See more
Orthologs

Genomic context

See SCTR in Genome Data Viewer
Location:
2q14.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (119439843..119524483, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (120197419..120282028, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene diazepam binding inhibitor, acyl-CoA binding protein Neighboring gene transmembrane protein 37 Neighboring gene VISTA enhancer hs1941 Neighboring gene SCTR antisense RNA 1 Neighboring gene cilia and flagella associated protein 221 Neighboring gene transmembrane protein 177 Neighboring gene ribosomal protein L17 pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
secretin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
secretin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular water homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
diet induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cAMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of appetite ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
response to nutrient levels ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
secretin receptor
Names
pancreatic secretin receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029904.1 RefSeqGene

    Range
    5001..89610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002980.3NP_002971.2  secretin receptor precursor

    See identical proteins and their annotated locations for NP_002971.2

    Status: REVIEWED

    Source sequence(s)
    AC013275
    Consensus CDS
    CCDS2127.1
    UniProtKB/Swiss-Prot
    P47872
    UniProtKB/TrEMBL
    Q8IV17
    Related
    ENSP00000019103.5, ENST00000019103.7
    Conserved Domains (2) summary
    pfam00002
    Location:139384
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:64126
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    119439843..119524483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004671.1XP_016860160.1  secretin receptor isoform X3

  2. XM_011511621.2XP_011509923.1  secretin receptor isoform X1

    Conserved Domains (2) summary
    pfam00002
    Location:139389
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:64126
    HRM; Hormone receptor domain
  3. XM_017004670.1XP_016860159.1  secretin receptor isoform X2

  4. XM_017004672.1XP_016860161.1  secretin receptor isoform X4

  5. XM_024453038.1XP_024308806.1  secretin receptor isoform X5

    Conserved Domains (2) summary
    pfam02793
    Location:158
    HRM; Hormone receptor domain
    cd15275
    Location:71337
    7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
  6. XM_005263730.5XP_005263787.1  secretin receptor isoform X7

    Related
    ENST00000485440.1
    Conserved Domains (1) summary
    pfam00002
    Location:1206
    7tm_2; 7 transmembrane receptor (Secretin family)
  7. XM_017004673.1XP_016860162.1  secretin receptor isoform X6

RNA

  1. XR_001738887.1 RNA Sequence

  2. XR_922984.2 RNA Sequence

  3. XR_001738889.1 RNA Sequence

  4. XR_001738888.1 RNA Sequence

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