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SCML1 Scm polycomb group protein like 1 [ Homo sapiens (human) ]

Gene ID: 6322, updated on 7-Jun-2020

Summary

Official Symbol
SCML1provided by HGNC
Official Full Name
Scm polycomb group protein like 1provided by HGNC
Primary source
HGNC:HGNC:10580
See related
Ensembl:ENSG00000047634 MIM:300227
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 14.0), ovary (RPKM 6.6) and 24 other tissues See more
Orthologs

Genomic context

See SCML1 in Genome Data Viewer
Location:
Xp22.13
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (17737449..17754988)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (17755591..17773105)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene NHS actin remodeling regulator Neighboring gene uncharacterized LOC105373142 Neighboring gene CHP1 pseudogene 3 Neighboring gene family with sequence similarity 136 member A pseudogene Neighboring gene retinoic acid induced 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sex comb on midleg-like protein 1
Names
sex comb on midleg like 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037535.2NP_001032624.1  sex comb on midleg-like protein 1 isoform c

    See identical proteins and their annotated locations for NP_001032624.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons and uses an alternate splice site in the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform (c).
    Source sequence(s)
    AA382395, AF160728, BC026159, Z93242
    Consensus CDS
    CCDS35211.1
    UniProtKB/Swiss-Prot
    Q9UN30
    UniProtKB/TrEMBL
    A0A024RBY0
    Related
    ENSP00000381154.1, ENST00000398080.5
    Conserved Domains (2) summary
    cd09578
    Location:131202
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:134202
    SAM; Sterile alpha motif
  2. NM_001037536.3NP_001032625.1  sex comb on midleg-like protein 1 isoform c

    See identical proteins and their annotated locations for NP_001032625.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two exons in the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform (c).
    Source sequence(s)
    AA382395, AF160728, BC026159
    Consensus CDS
    CCDS35211.1
    UniProtKB/Swiss-Prot
    Q9UN30
    UniProtKB/TrEMBL
    A0A024RBY0
    Related
    ENSP00000369384.3, ENST00000380045.7
    Conserved Domains (2) summary
    cd09578
    Location:131202
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:134202
    SAM; Sterile alpha motif
  3. NM_001037540.3NP_001032629.1  sex comb on midleg-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_001032629.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AA382395, AF160728, BC026159, BI461014
    Consensus CDS
    CCDS35210.1
    UniProtKB/Swiss-Prot
    Q9UN30
    Related
    ENSP00000369380.3, ENST00000380041.8
    Conserved Domains (2) summary
    cd09578
    Location:252323
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:255323
    SAM; Sterile alpha motif
  4. NM_006746.6NP_006737.2  sex comb on midleg-like protein 1 isoform b

    See identical proteins and their annotated locations for NP_006737.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AA382395, AF160728, BC026159
    Consensus CDS
    CCDS14182.2
    UniProtKB/Swiss-Prot
    Q9UN30
    UniProtKB/TrEMBL
    A0A024RBZ7
    Related
    ENSP00000369382.3, ENST00000380043.7
    Conserved Domains (2) summary
    cd09578
    Location:225296
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:228296
    SAM; Sterile alpha motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    17737449..17754988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274578.2XP_005274635.1  sex comb on midleg-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005274635.1

    Conserved Domains (2) summary
    cd09578
    Location:253324
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:256324
    SAM; Sterile alpha motif
  2. XM_005274579.2XP_005274636.1  sex comb on midleg-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_005274636.1

    Conserved Domains (2) summary
    cd09578
    Location:224295
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:227295
    SAM; Sterile alpha motif
  3. XM_011545564.3XP_011543866.1  sex comb on midleg-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543866.1

    Conserved Domains (2) summary
    cd09578
    Location:253324
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:256324
    SAM; Sterile alpha motif
  4. XM_006724508.4XP_006724571.1  sex comb on midleg-like protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006724571.1

    UniProtKB/Swiss-Prot
    Q9UN30
    Conserved Domains (2) summary
    cd09578
    Location:252323
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:255323
    SAM; Sterile alpha motif
  5. XM_017029723.2XP_016885212.1  sex comb on midleg-like protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q9UN30
    UniProtKB/TrEMBL
    A0A024RBZ7
    Conserved Domains (2) summary
    cd09578
    Location:225296
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:228296
    SAM; Sterile alpha motif
  6. XM_006724509.4XP_006724572.1  sex comb on midleg-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006724572.1

    Conserved Domains (2) summary
    cd09578
    Location:224295
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:227295
    SAM; Sterile alpha motif
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