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SCD stearoyl-CoA desaturase [ Homo sapiens (human) ]

Gene ID: 6319, updated on 18-Nov-2019

Summary

Official Symbol
SCDprovided by HGNC
Official Full Name
stearoyl-CoA desaturaseprovided by HGNC
Primary source
HGNC:HGNC:10571
See related
Ensembl:ENSG00000099194 MIM:604031
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCD1; FADS5; SCDOS; hSCD1; MSTP008
Summary
This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Sep 2015]
Expression
Biased expression in fat (RPKM 972.1), brain (RPKM 238.0) and 4 other tissues See more
Orthologs

Genomic context

See SCD in Genome Data Viewer
Location:
10q24.31
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (100347233..100364826)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (102106772..102124588)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene biogenesis of lysosomal organelles complex 1 subunit 2 Neighboring gene polycystin 2 like 1, transient receptor potential cation channel Neighboring gene oligodendrocyte maturation-associated long intergenic non-coding RNA Neighboring gene uncharacterized LOC105378452 Neighboring gene Wnt family member 8B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
NHGRI GWA Catalog
Human metabolic individuality in biomedical and pharmaceutical research.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of stearoyl-CoA desaturase (delta-9-desaturase; SCD) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 MA increases SCD mRNA expression in HepG2 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
iron ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
iron ion binding IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
palmitoyl-CoA 9-desaturase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
stearoyl-CoA 9-desaturase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stearoyl-CoA 9-desaturase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
fatty-acyl-CoA biosynthetic process TAS
Traceable Author Statement
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of cholesterol biosynthetic process TAS
Traceable Author Statement
more info
 
response to fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unsaturated fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unsaturated fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
acyl-CoA desaturase
Names
delta(9)-desaturase
fatty acid desaturase
predicted protein of HQ0998
stearoyl-CoA desaturase (delta-9-desaturase)
stearoyl-CoA desaturase opposite strand
NP_005054.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005063.5NP_005054.3  acyl-CoA desaturase

    See identical proteins and their annotated locations for NP_005054.3

    Status: REVIEWED

    Source sequence(s)
    AI761929, AK312312, AL139819, BC062303
    Consensus CDS
    CCDS7493.1
    UniProtKB/Swiss-Prot
    O00767
    Related
    ENSP00000359380.2, ENST00000370355.3
    Conserved Domains (2) summary
    cd03505
    Location:100337
    Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
    pfam00487
    Location:102306
    FA_desaturase; Fatty acid desaturase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    100347233..100364826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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