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CELA2A chymotrypsin like elastase 2A [ Homo sapiens (human) ]

Gene ID: 63036, updated on 1-Jun-2020

Summary

Official Symbol
CELA2Aprovided by HGNC
Official Full Name
chymotrypsin like elastase 2Aprovided by HGNC
Primary source
HGNC:HGNC:24609
See related
Ensembl:ENSG00000142615 MIM:609443
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PE-1; AOMS4; ELA2A
Summary
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, May 2009]
Expression
Restricted expression toward pancreas (RPKM 18580.0) See more
Orthologs

Genomic context

See CELA2A in Genome Data Viewer
Location:
1p36.21
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (15456732..15472091)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (15783223..15798586)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927441 Neighboring gene EF-hand domain family member D2 Neighboring gene chymotrypsin C Neighboring gene uncharacterized LOC105376767 Neighboring gene chymotrypsin like elastase 2B Neighboring gene caspase 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
NHGRI GWA Catalog

Pathways from PubChem

General gene information

Markers

Potential readthrough

Included gene: CELA2B

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
insulin catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
regulation of platelet aggregation IDA
Inferred from Direct Assay
more info
PubMed 
response to insulin IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
keratohyalin granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
chymotrypsin-like elastase family member 2A
Names
chymotrypsin like elastase family member 2A
elastase 2A
pancreatic elastase 2
pancreatic elastase IIA
NP_254275.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033440.3NP_254275.1  chymotrypsin-like elastase family member 2A preproprotein

    See identical proteins and their annotated locations for NP_254275.1

    Status: REVIEWED

    Source sequence(s)
    BC007031, BQ787677
    Consensus CDS
    CCDS157.1
    UniProtKB/Swiss-Prot
    P08217
    Related
    ENSP00000352639.4, ENST00000359621.5
    Conserved Domains (1) summary
    cd00190
    Location:29265
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    15456732..15472091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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