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SLC22A23 solute carrier family 22 member 23 [ Homo sapiens (human) ]

Gene ID: 63027, updated on 7-Jun-2020

Summary

Official Symbol
SLC22A23provided by HGNC
Official Full Name
solute carrier family 22 member 23provided by HGNC
Primary source
HGNC:HGNC:21106
See related
Ensembl:ENSG00000137266 MIM:611697
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C6orf85
Summary
SLC22A23 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in stomach (RPKM 8.9), colon (RPKM 8.8) and 25 other tissues See more
Orthologs

Genomic context

See SLC22A23 in Genome Data Viewer
Location:
6p25.2
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (3268973..3457050, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (3269207..3456954, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100422781 Neighboring gene tubulin beta 2B class IIb Neighboring gene proteasome assembly chaperone 4 Neighboring gene VISTA enhancer hs1391 Neighboring gene HNF4 motif-containing MPRA enhancer 213 Neighboring gene uncharacterized LOC105374890 Neighboring gene Sharpr-MPRA regulatory region 3383 Neighboring gene uncharacterized LOC643327 Neighboring gene uncharacterized LOC100507336 Neighboring gene translocase of outer mitochondrial membrane 5 homolog (yeast) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of antipsychotic-induced QTc interval prolongation.
NHGRI GWA Catalog
Genome-wide association study of serious blistering skin rash caused by drugs.
NHGRI GWA Catalog
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
NHGRI GWA Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22174, DKFZp434F011

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ion transport IEA
Inferred from Electronic Annotation
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
solute carrier family 22 member 23
Names
ion transporter protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286455.1NP_001273384.1  solute carrier family 22 member 23 isoform b

    See identical proteins and their annotated locations for NP_001273384.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AJ420525, AK172770, BC128580, DB050701
    Consensus CDS
    CCDS34331.1
    UniProtKB/Swiss-Prot
    A1A5C7
    Related
    ENSP00000369657.4, ENST00000380302.8
    Conserved Domains (1) summary
    cl26863
    Location:1347
    Sugar_tr; Sugar (and other) transporter
  2. NM_001286456.2NP_001273385.1  solute carrier family 22 member 23 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks multiple exons in the 3' region but includes an alternate 3' exon, and it thus lacks a portion of the 3' coding region and differs in the 3' UTR, compared to variant 1. The encoded isoform (c) is shorter at the C-terminus, compared to isoform a.
    Source sequence(s)
    AL160398, AL445309
    Consensus CDS
    CCDS75389.1
    UniProtKB/Swiss-Prot
    A1A5C7
    UniProtKB/TrEMBL
    Q9UFY2
    Related
    ENSP00000369653.2, ENST00000380298.2
    Conserved Domains (2) summary
    cd06174
    Location:235360
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:95360
    2A0119; cation transport protein
  3. NM_001382317.1NP_001369246.1  solute carrier family 22 member 23 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL160398, AL445309
  4. NM_001382318.1NP_001369247.1  solute carrier family 22 member 23 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL445309
  5. NM_001382319.1NP_001369248.1  solute carrier family 22 member 23 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL445309
  6. NM_001382320.1NP_001369249.1  solute carrier family 22 member 23 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL160398, AL445309
  7. NM_001382321.1NP_001369250.1  solute carrier family 22 member 23 isoform h

    Status: VALIDATED

    Source sequence(s)
    AL445309
  8. NM_015482.2NP_056297.1  solute carrier family 22 member 23 isoform a

    See identical proteins and their annotated locations for NP_056297.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL160398, AL445309
    Consensus CDS
    CCDS47363.1
    UniProtKB/Swiss-Prot
    A1A5C7
    Related
    ENSP00000385028.3, ENST00000406686.7
    Conserved Domains (2) summary
    cd06174
    Location:235364
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:95628
    2A0119; cation transport protein
  9. NM_021945.6NP_068764.3  solute carrier family 22 member 23 isoform b

    See identical proteins and their annotated locations for NP_068764.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AJ420525, AK172770, BC038748, DB050701
    Consensus CDS
    CCDS34331.1
    UniProtKB/Swiss-Prot
    A1A5C7
    Related
    ENSP00000419463.1, ENST00000490273.5
    Conserved Domains (1) summary
    cl26863
    Location:1347
    Sugar_tr; Sugar (and other) transporter

RNA

  1. NR_104448.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains alternate 5' exon structure, includes an additional exon in the central region, and lacks a segment in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AJ420525, AK172770, BC128581, DB050701
  2. NR_168069.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL160398, AL445309

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    3268973..3457050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514801.2XP_011513103.1  solute carrier family 22 member 23 isoform X1

    Conserved Domains (2) summary
    cd06174
    Location:259388
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:243652
    2A0119; cation transport protein
  2. XM_017011186.1XP_016866675.1  solute carrier family 22 member 23 isoform X3

    UniProtKB/Swiss-Prot
    A1A5C7
    Conserved Domains (1) summary
    cl26863
    Location:1347
    Sugar_tr; Sugar (and other) transporter
  3. XM_017011180.1XP_016866669.1  solute carrier family 22 member 23 isoform X2

  4. XM_017011181.1XP_016866670.1  solute carrier family 22 member 23 isoform X3

    UniProtKB/Swiss-Prot
    A1A5C7
    Conserved Domains (1) summary
    cl26863
    Location:1347
    Sugar_tr; Sugar (and other) transporter
  5. XM_017011184.1XP_016866673.1  solute carrier family 22 member 23 isoform X6

  6. XM_017011185.2XP_016866674.1  solute carrier family 22 member 23 isoform X7

  7. XM_017011183.1XP_016866672.1  solute carrier family 22 member 23 isoform X5

RNA

  1. XR_001743575.1 RNA Sequence

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