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TSPAN31 tetraspanin 31 [ Homo sapiens (human) ]

Gene ID: 6302, updated on 11-Sep-2019

Summary

Official Symbol
TSPAN31provided by HGNC
Official Full Name
tetraspanin 31provided by HGNC
Primary source
HGNC:HGNC:10539
See related
Ensembl:ENSG00000135452 MIM:181035
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAS
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 18.9), adrenal (RPKM 13.0) and 25 other tissues See more
Orthologs

Genomic context

See TSPAN31 in Genome Data Viewer
Location:
12q14.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (57745039..57750219)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (58138784..58142026)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene OS9 endoplasmic reticulum lectin Neighboring gene AGAP2 antisense RNA 1 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 Neighboring gene microRNA 6759 Neighboring gene cyclin dependent kinase 4 Neighboring gene membrane associated ring-CH-type finger 9 Neighboring gene cytochrome P450 family 27 subfamily B member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
tetraspanin-31
Names
sarcoma-amplified sequence
transmembrane 4 protein
tspan-31

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330168.2NP_001317097.1  tetraspanin-31 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two consecutive exons in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter but has the same N- and C-termini as isoform 1
    Source sequence(s)
    AC025165, CN479167, DC392401, U01160
    Consensus CDS
    CCDS86313.1
    UniProtKB/Swiss-Prot
    Q12999
    UniProtKB/TrEMBL
    F8VWE0
    Related
    ENSP00000449199.1, ENST00000547472.5
  2. NM_001330169.2NP_001317098.1  tetraspanin-31 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in its 5' terminal exon compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (3) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC025165, AK294128, CN479167, DC392401, U01160
    UniProtKB/Swiss-Prot
    Q12999
    UniProtKB/TrEMBL
    B4DFJ7
    Conserved Domains (1) summary
    cl02781
    Location:2121
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
  3. NM_005981.5NP_005972.1  tetraspanin-31 isoform 1

    See identical proteins and their annotated locations for NP_005972.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC025165, CN479167, DC392401, U01160
    Consensus CDS
    CCDS8952.1
    UniProtKB/Swiss-Prot
    Q12999
    Related
    ENSP00000257910.3, ENST00000257910.8
    Conserved Domains (1) summary
    pfam00335
    Location:9199
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    57745039..57750219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449123.1XP_024304891.1  tetraspanin-31 isoform X1

    Conserved Domains (1) summary
    cl02781
    Location:2121
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
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