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Serpina3i serine (or cysteine) peptidase inhibitor, clade A, member 3I [ Mus musculus (house mouse) ]

Gene ID: 628900, updated on 26-Sep-2022

Summary

Official Symbol
Serpina3iprovided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade A, member 3Iprovided by MGI
Primary source
MGI:MGI:2182841
See related
Ensembl:ENSMUSG00000079014 AllianceGenome:MGI:2182841
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2B2; Gm6930; EG628900
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within response to cytokine and response to peptide hormone. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 2.5), spleen adult (RPKM 1.1) and 9 other tissues See more
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Genomic context

See Serpina3i in Genome Data Viewer
Location:
12; 12 E
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (104229304..104235768)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (104263045..104269509)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3G Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3H Neighboring gene microRNA 12183 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3K

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General protein information

Preferred Names
serine (or cysteine) peptidase inhibitor, clade A, member 3I
Names
alpha-1 antiproteinase
antitrypsin
serine (or cysteine) proteinase inhibitor, clade A, member 3I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199940.1NP_001186869.1  serine (or cysteine) peptidase inhibitor, clade A, member 3I

    Status: VALIDATED

    Source sequence(s)
    AC142112, BY136799, CJ239048
    Consensus CDS
    CCDS49157.1
    UniProtKB/TrEMBL
    D3Z450
    Related
    ENSMUSP00000105584.3, ENSMUST00000109958.3
    Conserved Domains (1) summary
    smart00093
    Location:46407
    SERPIN; SERine Proteinase INhibitors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    104229304..104235768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315152.1XP_017170641.1  serine (or cysteine) peptidase inhibitor, clade A, member 3I isoform X1

    Conserved Domains (1) summary
    cd19551
    Location:62457
    serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin
  2. XM_006516132.3XP_006516195.1  serine (or cysteine) peptidase inhibitor, clade A, member 3I isoform X2

    Conserved Domains (1) summary
    cd19551
    Location:62456
    serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin
  3. XM_017315153.1XP_017170642.1  serine (or cysteine) peptidase inhibitor, clade A, member 3I isoform X3

    Conserved Domains (1) summary
    cd19551
    Location:62443
    serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin
  4. XM_036157556.1XP_036013449.1  serine (or cysteine) peptidase inhibitor, clade A, member 3I isoform X5

    Conserved Domains (1) summary
    cl38926
    Location:62237
    serpin; SERine Proteinase INhibitors (serpin) family
  5. XM_017315154.1XP_017170643.1  serine (or cysteine) peptidase inhibitor, clade A, member 3I isoform X4

    Conserved Domains (1) summary
    cl38926
    Location:62238
    serpin; SERine Proteinase INhibitors (serpin) family