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S100A13 S100 calcium binding protein A13 [ Homo sapiens (human) ]

Gene ID: 6284, updated on 8-Dec-2018

Summary

Official Symbol
S100A13provided by HGNC
Official Full Name
S100 calcium binding protein A13provided by HGNC
Primary source
HGNC:HGNC:10490
See related
Ensembl:ENSG00000189171 MIM:601989
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in heart (RPKM 156.8), fat (RPKM 39.4) and 16 other tissues See more
Orthologs

Genomic context

See S100A13 in Genome Data Viewer
Location:
1q21.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (153618799..153634092, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153591275..153606582, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A16 Neighboring gene S100 calcium binding protein A14 Neighboring gene S100 calcium binding protein A1 Neighboring gene chromatin target of PRMT1 Neighboring gene SNAP associated protein Neighboring gene interleukin enhancer binding factor 2 Neighboring gene transfer RNA-iMet (CAT) 1-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RAGE receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
copper ion binding IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cytokine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-1 alpha secretion IDA
Inferred from Direct Assay
more info
PubMed 
mast cell degranulation NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
response to copper ion IEA
Inferred from Electronic Annotation
more info
 
response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
mast cell granule IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024210.1NP_001019381.1  protein S100-A13

    See identical proteins and their annotated locations for NP_001019381.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    BC000632, CK817939
    Consensus CDS
    CCDS30874.1
    UniProtKB/Swiss-Prot
    Q99584
    Conserved Domains (1) summary
    cd05022
    Location:788
    S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
  2. NM_001024211.1NP_001019382.1  protein S100-A13

    See identical proteins and their annotated locations for NP_001019382.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has a distinct and shorter 5' UTR, as compared to variant 1.
    Source sequence(s)
    BC000632, BM913375
    Consensus CDS
    CCDS30874.1
    UniProtKB/Swiss-Prot
    Q99584
    Conserved Domains (1) summary
    cd05022
    Location:788
    S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
  3. NM_001024212.1NP_001019383.1  protein S100-A13

    See identical proteins and their annotated locations for NP_001019383.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has a distinct and shorter 5' UTR, as compared to variant 1.
    Source sequence(s)
    BC000632, BM762088
    Consensus CDS
    CCDS30874.1
    UniProtKB/Swiss-Prot
    Q99584
    Related
    ENSP00000376399.1, ENST00000392623.5
    Conserved Domains (1) summary
    cd05022
    Location:788
    S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
  4. NM_001024213.1NP_001019384.1  protein S100-A13

    See identical proteins and their annotated locations for NP_001019384.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has a distinct and shorter 5' UTR, as compared to variant 1.
    Source sequence(s)
    AA366085, BC000632, BX472819
    Consensus CDS
    CCDS30874.1
    UniProtKB/Swiss-Prot
    Q99584
    Related
    ENSP00000376398.1, ENST00000392622.3
    Conserved Domains (1) summary
    cd05022
    Location:788
    S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
  5. NM_005979.2NP_005970.1  protein S100-A13

    See identical proteins and their annotated locations for NP_005970.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a distinct and shorter 5' UTR, as compared to variant 1.
    Source sequence(s)
    BC000632, BC070291
    Consensus CDS
    CCDS30874.1
    UniProtKB/Swiss-Prot
    Q99584
    Related
    ENSP00000392767.2, ENST00000440685.6
    Conserved Domains (1) summary
    cd05022
    Location:788
    S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    153618799..153634092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509863.3XP_011508165.1  protein S100-A13 isoform X1

    See identical proteins and their annotated locations for XP_011508165.1

    UniProtKB/Swiss-Prot
    Q99584
    Conserved Domains (1) summary
    cd05022
    Location:788
    S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
  2. XM_017002034.2XP_016857523.1  protein S100-A13 isoform X1

    UniProtKB/Swiss-Prot
    Q99584
    Conserved Domains (1) summary
    cd05022
    Location:788
    S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
  3. XM_017002035.2XP_016857524.1  protein S100-A13 isoform X1

    UniProtKB/Swiss-Prot
    Q99584
    Conserved Domains (1) summary
    cd05022
    Location:788
    S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
  4. XM_011509862.3XP_011508164.1  protein S100-A13 isoform X1

    See identical proteins and their annotated locations for XP_011508164.1

    UniProtKB/Swiss-Prot
    Q99584
    Conserved Domains (1) summary
    cd05022
    Location:788
    S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
  5. XM_005245434.3XP_005245491.1  protein S100-A13 isoform X1

    See identical proteins and their annotated locations for XP_005245491.1

    UniProtKB/Swiss-Prot
    Q99584
    Conserved Domains (1) summary
    cd05022
    Location:788
    S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
  6. XM_011509864.2XP_011508166.1  protein S100-A13 isoform X1

    See identical proteins and their annotated locations for XP_011508166.1

    UniProtKB/Swiss-Prot
    Q99584
    Conserved Domains (1) summary
    cd05022
    Location:788
    S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
  7. XM_017002036.1XP_016857525.1  protein S100-A13 isoform X1

    UniProtKB/Swiss-Prot
    Q99584
    Conserved Domains (1) summary
    cd05022
    Location:788
    S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
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