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S100A10 S100 calcium binding protein A10 [ Homo sapiens (human) ]

Gene ID: 6281, updated on 4-Nov-2018

Summary

Official Symbol
S100A10provided by HGNC
Official Full Name
S100 calcium binding protein A10provided by HGNC
Primary source
HGNC:HGNC:10487
See related
Ensembl:ENSG00000197747 MIM:114085; Vega:OTTHUMG00000013068
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
42C; P11; p10; GP11; ANX2L; CAL1L; CLP11; Ca[1]; ANX2LG
Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in colon (RPKM 299.3), esophagus (RPKM 210.9) and 22 other tissues See more
Orthologs

Genomic context

See S100A10 in Genome Data Viewer
Location:
1q21.3
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (151982910..151994238, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151955386..151966714, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene thioesterase superfamily member 4 Neighboring gene keratin 8 pseudogene 28 Neighboring gene uncharacterized LOC105371441 Neighboring gene uncharacterized LOC105371442 Neighboring gene NBPF member 18, pseudogene Neighboring gene S100 calcium binding protein A11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Dissolution of Fibrin Clot, organism-specific biosystem (from REACTOME)
    Dissolution of Fibrin Clot, organism-specific biosystemThe crosslinked fibrin multimers in a clot are broken down to soluble polypeptides by plasmin, a serine protease. Plasmin can be generated from its inactive precursor plasminogen and recruited to the...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Prostaglandin Synthesis and Regulation, organism-specific biosystem (from WikiPathways)
    Prostaglandin Synthesis and Regulation, organism-specific biosystemA prostaglandin is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon ato...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111133

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein S100-A10
Names
S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11))
annexin II ligand, calpactin I, light polypeptide
annexin II tetramer (AIIt) p11 subunit
calpactin I light chain
calpactin-1 light chain
cellular ligand of annexin II

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002966.2NP_002957.1  protein S100-A10

    See identical proteins and their annotated locations for NP_002957.1

    Status: REVIEWED

    Source sequence(s)
    BE378444, BI827113, BQ050753
    Consensus CDS
    CCDS1008.1
    UniProtKB/Swiss-Prot
    P60903
    Related
    ENSP00000357801.3, OTTHUMP00000015269, ENST00000368811.7, OTTHUMT00000036673
    Conserved Domains (1) summary
    cd05024
    Location:393
    S-100A10; S-100A10: A subgroup of the S-100A10 domain found in proteins similar to S100A10. S100A10 is a member of the S100 family of EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which this S-100A10 group belongs, contains ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    151982910..151994238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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