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S100A8 S100 calcium binding protein A8 [ Homo sapiens (human) ]

Gene ID: 6279, updated on 12-Oct-2019

Summary

Official Symbol
S100A8provided by HGNC
Official Full Name
S100 calcium binding protein A8provided by HGNC
Primary source
HGNC:HGNC:10498
See related
Ensembl:ENSG00000143546 MIM:123885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P8; MIF; NIF; CAGA; CFAG; CGLA; L1Ag; MRP8; CP-10; MA387; 60B8AG
Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Expression
Biased expression in bone marrow (RPKM 3778.8), esophagus (RPKM 2115.4) and 1 other tissue See more
Orthologs

Genomic context

See S100A8 in Genome Data Viewer
Location:
1q21.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (153390032..153422583, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153362508..153395054, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A12 Neighboring gene lysosomal protein transmembrane 4 beta pseudogene 1 Neighboring gene S100 calcium binding protein A15A (pseudogene) Neighboring gene S100 calcium binding protein A7A Neighboring gene S100 calcium binding protein A7 pseudogene 1 Neighboring gene S100 calcium binding protein A7 like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Antimicrobial peptides, organism-specific biosystem (from REACTOME)
    Antimicrobial peptides, organism-specific biosystemAntimicrobial peptides (AMPs) are small molecular weight proteins with broad spectrum of antimicrobial activity against bacteria, viruses, and fungi (Zasloff M 2002; Radek K & Gallo R 2007). The majo...
  • IL-17 signaling pathway, organism-specific biosystem (from KEGG)
    IL-17 signaling pathway, organism-specific biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
  • IL-17 signaling pathway, conserved biosystem (from KEGG)
    IL-17 signaling pathway, conserved biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Metal sequestration by antimicrobial proteins, organism-specific biosystem (from REACTOME)
    Metal sequestration by antimicrobial proteins, organism-specific biosystemMetals are necessary for all forms of life including microorganisms, evidenced by the fact that metal cations are constituents of approximately 40% of all proteins crystallized to date (Waldron KJ et...
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Regulation of TLR by endogenous ligand, organism-specific biosystem (from REACTOME)
    Regulation of TLR by endogenous ligand, organism-specific biosystemDiverse molecules of host-cell origin may serve as endogenous ligands of Toll-like receptors (TLRs) (Erridge C 2010; Piccinini AM & Midwood KS 2010). These molecules are known as damage-associated mo...
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RAGE receptor binding TAS
Traceable Author Statement
more info
PubMed 
Toll-like receptor 4 binding TAS
Traceable Author Statement
more info
PubMed 
arachidonic acid binding TAS
Traceable Author Statement
more info
PubMed 
calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
microtubule binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acute inflammatory response IEA
Inferred from Electronic Annotation
more info
 
antimicrobial humoral response TAS
Traceable Author Statement
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
astrocyte development IEA
Inferred from Electronic Annotation
more info
 
autocrine signaling IEA
Inferred from Electronic Annotation
more info
 
autophagy IDA
Inferred from Direct Assay
more info
PubMed 
chemokine production TAS
Traceable Author Statement
more info
PubMed 
chronic inflammatory response IEA
Inferred from Electronic Annotation
more info
 
cytokine production TAS
Traceable Author Statement
more info
PubMed 
defense response to bacterium TAS
Traceable Author Statement
more info
PubMed 
defense response to fungus TAS
Traceable Author Statement
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
leukocyte migration involved in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil aggregation IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
peptidyl-cysteine S-nitrosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell growth TAS
Traceable Author Statement
more info
PubMed 
positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptide secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to zinc ion IEA
Inferred from Electronic Annotation
more info
 
sequestering of zinc ion TAS
Traceable Author Statement
more info
PubMed 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
wound healing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
collagen-containing extracellular matrix HDA PubMed 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 
nucleus HDA PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein S100-A8
Names
calgranulin A
calprotectin L1L subunit
cystic fibrosis antigen
leukocyte L1 complex light chain
migration inhibitory factor-related protein 8
urinary stone protein band A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319196.1NP_001306125.1  protein S100-A8 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BP209293, BU935536
    Conserved Domains (2) summary
    cd05030
    Location:27110
    calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...
    pfam13499
    Location:5599
    EF-hand_7; EF-hand domain pair
  2. NM_001319197.1NP_001306126.1  protein S100-A8 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
    Source sequence(s)
    BP226540, BU935536, X06234
    UniProtKB/Swiss-Prot
    P05109
    Conserved Domains (2) summary
    cd05030
    Location:26109
    calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...
    pfam13499
    Location:5498
    EF-hand_7; EF-hand domain pair
  3. NM_001319198.1NP_001306127.1  protein S100-A8 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AA401538, AI126134, X06234
    UniProtKB/Swiss-Prot
    P05109
    Conserved Domains (2) summary
    cd05030
    Location:1194
    calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...
    pfam13499
    Location:3983
    EF-hand_7; EF-hand domain pair
  4. NM_001319201.1NP_001306130.1  protein S100-A8 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
    Source sequence(s)
    AA903259, X06234
    Consensus CDS
    CCDS1038.1
    UniProtKB/Swiss-Prot
    P05109
    Related
    ENSP00000357721.1, ENST00000368732.5
    Conserved Domains (1) summary
    cd05030
    Location:386
    calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...
  5. NM_002964.5NP_002955.2  protein S100-A8 isoform d

    See identical proteins and their annotated locations for NP_002955.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
    Source sequence(s)
    AK291328, X06234
    Consensus CDS
    CCDS1038.1
    UniProtKB/Swiss-Prot
    P05109
    Related
    ENSP00000357722.3, ENST00000368733.4
    Conserved Domains (1) summary
    cd05030
    Location:386
    calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    153390032..153422583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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