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S100A8 S100 calcium binding protein A8 [ Homo sapiens (human) ]

Gene ID: 6279, updated on 3-Nov-2024

Summary

Official Symbol
S100A8provided by HGNC
Official Full Name
S100 calcium binding protein A8provided by HGNC
Primary source
HGNC:HGNC:10498
See related
Ensembl:ENSG00000143546 MIM:123885; AllianceGenome:HGNC:10498
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P8; MIF; NIF; CAGA; CFAG; CGLA; L1Ag; MRP8; CP-10; MA387; 60B8AG; S100-A8
Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Expression
Biased expression in bone marrow (RPKM 3778.8), esophagus (RPKM 2115.4) and 1 other tissue See more
Orthologs
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Genomic context

See S100A8 in Genome Data Viewer
Location:
1q21.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153390032..153422583, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152527256..152559808, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153362508..153395059, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A12 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:153352860-153353030 Neighboring gene lysosomal protein transmembrane 4 beta pseudogene 1 Neighboring gene MPRA-validated peak414 silencer Neighboring gene S100 calcium binding protein A15A (pseudogene) Neighboring gene S100 calcium binding protein A7A Neighboring gene S100 calcium binding protein A7 pseudogene 1 Neighboring gene CRISPRi-validated cis-regulatory element chr1.8681 Neighboring gene S100 calcium binding protein A7 like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RAGE receptor binding TAS
Traceable Author Statement
more info
PubMed 
enables Toll-like receptor 4 binding TAS
Traceable Author Statement
more info
PubMed 
enables arachidonate binding TAS
Traceable Author Statement
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
enables calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in astrocyte development IEA
Inferred from Electronic Annotation
more info
 
involved_in autocrine signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in autophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chronic inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to bacterium TAS
Traceable Author Statement
more info
PubMed 
involved_in defense response to fungus TAS
Traceable Author Statement
more info
PubMed 
involved_in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte migration involved in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in leukocyte migration involved in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neutrophil aggregation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neutrophil aggregation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptide secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-cysteine S-nitrosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of cell growth TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptide secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of toll-like receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to zinc ion IEA
Inferred from Electronic Annotation
more info
 
involved_in sequestering of zinc ion TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
protein S100-A8
Names
calgranulin A
calprotectin L1L subunit
cystic fibrosis antigen
leukocyte L1 complex light chain
migration inhibitory factor-related protein 8
urinary stone protein band A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319196.1NP_001306125.1  protein S100-A8 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BP209293, BU935536
    Conserved Domains (2) summary
    cd05030
    Location:27110
    calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...
    pfam13499
    Location:5599
    EF-hand_7; EF-hand domain pair
  2. NM_001319197.1NP_001306126.1  protein S100-A8 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
    Source sequence(s)
    BP226540, BU935536, X06234
    UniProtKB/Swiss-Prot
    P05109
    Conserved Domains (2) summary
    cd05030
    Location:26109
    calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...
    pfam13499
    Location:5498
    EF-hand_7; EF-hand domain pair
  3. NM_001319198.2NP_001306127.1  protein S100-A8 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AA401538, AI126134, X06234
    UniProtKB/Swiss-Prot
    P05109
    Conserved Domains (2) summary
    cd05030
    Location:1194
    calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...
    pfam13499
    Location:3983
    EF-hand_7; EF-hand domain pair
  4. NM_001319201.2NP_001306130.1  protein S100-A8 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
    Source sequence(s)
    AA903259, X06234
    Consensus CDS
    CCDS1038.1
    UniProtKB/Swiss-Prot
    A8K5L3, D3DV37, P05109, Q5SY70, Q9UC84, Q9UC92, Q9UCJ0, Q9UCM6
    Related
    ENSP00000357721.1, ENST00000368732.5
    Conserved Domains (1) summary
    cd05030
    Location:386
    calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...
  5. NM_002964.5NP_002955.2  protein S100-A8 isoform d

    See identical proteins and their annotated locations for NP_002955.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
    Source sequence(s)
    AK291328, X06234
    Consensus CDS
    CCDS1038.1
    UniProtKB/Swiss-Prot
    A8K5L3, D3DV37, P05109, Q5SY70, Q9UC84, Q9UC92, Q9UCJ0, Q9UCM6
    Related
    ENSP00000357722.3, ENST00000368733.4
    Conserved Domains (1) summary
    cd05030
    Location:386
    calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    153390032..153422583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    152527256..152559808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)