Lrrc74a leucine rich repeat containing 74A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrrc74aprovided by MGI
Official Full Name: leucine rich repeat containing 74Aprovided by MGI
Primary source: MGI:MGI:3646959
See related: Ensembl:ENSMUSG00000059114 AllianceGenome:MGI:3646959
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm6772; Lrrc74; EG627607
Summary: Orthologous to human LRRC74A (leucine rich repeat containing 74A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 21.3) See more
Orthologs: human all
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Genomic context

Location:: 12; 12 D2

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (86781119..86815799)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (86734345..86769025)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D12Mit258 (e-PCR), detects polymorphism
- UniSTS:126817

NoName (e-PCR)
- UniSTS:494712

AI507006 (e-PCR)
- UniSTS:165832

Homology

Homologs of the Lrrc74a gene: The Lrrc74a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Orthologs from Annotation Pipeline: 473 organisms have orthologs with human gene Lrrc74a
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: leucine-rich repeat-containing protein 74A

Names: leucine rich repeat containing 74

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001195767.2 → NP_001182696.1 leucine-rich repeat-containing protein 74A

See identical proteins and their annotated locations for NP_001182696.1

Status: VALIDATED

Source sequence(s)

AC102689

Consensus CDS

CCDS56848.1

UniProtKB/TrEMBL

F6QBN8

Related

ENSMUSP00000093183.6, ENSMUST00000095527.6

Conserved Domains (2) summary

sd00033
Location:148 → 176

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:73 → 333

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001418263.1 → NP_001405192.1 leucine-rich repeat-containing protein 74A

Status: VALIDATED

Source sequence(s)

AC102689

RNA

NR_184703.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC102689
NR_184704.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC102689

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

86781119..86815799

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246837.2 → XP_030102697.1 leucine-rich repeat-containing protein 74A isoform X2

Conserved Domains (2) summary

sd00033
Location:110 → 138

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:70 → 295

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_006516126.3 → XP_006516189.1 leucine-rich repeat-containing protein 74A isoform X1

See identical proteins and their annotated locations for XP_006516189.1

UniProtKB/TrEMBL

F6QBN8

Conserved Domains (2) summary

sd00033
Location:148 → 176

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:73 → 333

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_006516127.4 → XP_006516190.1 leucine-rich repeat-containing protein 74A isoform X1

See identical proteins and their annotated locations for XP_006516190.1

UniProtKB/TrEMBL

F6QBN8

Conserved Domains (2) summary

sd00033
Location:148 → 176

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:73 → 333

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_011244155.4 → XP_011242457.1 leucine-rich repeat-containing protein 74A isoform X1

See identical proteins and their annotated locations for XP_011242457.1

UniProtKB/TrEMBL

F6QBN8

Conserved Domains (2) summary

sd00033
Location:148 → 176

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:73 → 333

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_030246838.1 → XP_030102698.1 leucine-rich repeat-containing protein 74A isoform X3

Conserved Domains (2) summary

sd00033
Location:59 → 87

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:2 → 244

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_030246839.2 → XP_030102699.1 leucine-rich repeat-containing protein 74A isoform X5

Conserved Domains (2) summary

sd00034
Location:8 → 32

LRR_AMN1; leucine-rich repeat [structural motif]

cl39015
Location:8 → 150

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_017315150.2 → XP_017170639.1 leucine-rich repeat-containing protein 74A isoform X1

UniProtKB/TrEMBL

F6QBN8

Related

ENSMUSP00000152661.2, ENSMUST00000223308.2

Conserved Domains (2) summary

sd00033
Location:148 → 176

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:73 → 333

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_017315151.2 → XP_017170640.1 leucine-rich repeat-containing protein 74A isoform X2

Conserved Domains (2) summary

sd00033
Location:110 → 138

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:70 → 295

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_006516130.2 → XP_006516193.1 leucine-rich repeat-containing protein 74A isoform X4

See identical proteins and their annotated locations for XP_006516193.1

Conserved Domains (2) summary

sd00033
Location:148 → 176

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:73 → 256

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...