U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

S100A2 S100 calcium binding protein A2 [ Homo sapiens (human) ]

Gene ID: 6273, updated on 27-Nov-2024

Summary

Official Symbol
S100A2provided by HGNC
Official Full Name
S100 calcium binding protein A2provided by HGNC
Primary source
HGNC:HGNC:10492
See related
Ensembl:ENSG00000196754 MIM:176993; AllianceGenome:HGNC:10492
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAN19; S100L
Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008]
Expression
Biased expression in esophagus (RPKM 199.3), urinary bladder (RPKM 56.6) and 2 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See S100A2 in Genome Data Viewer
Location:
1q21.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153561108..153565844, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152698363..152703111, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153533584..153538320, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153517191-153517771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153517772-153518352 Neighboring gene uncharacterized LOC101928034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153521261-153521822 Neighboring gene Sharpr-MPRA regulatory region 14368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153522386-153522947 Neighboring gene S100 calcium binding protein A4 Neighboring gene S100 calcium binding protein A3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153536677-153537434 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153537435-153538192 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:153538345-153539544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153539708-153540464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1749 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153546964-153547744 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153547745-153548525 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153550484-153551282 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153555559-153556483 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153577506-153578461 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:153580804-153582003 Neighboring gene S100 calcium binding protein A16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153588740-153589240 Neighboring gene S100 calcium binding protein A14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC111539

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
enables calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in endothelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366406.1NP_001353335.1  protein S100-A2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    BX470102
    Consensus CDS
    CCDS91059.1
    UniProtKB/TrEMBL
    A6NDF0, Q5RHS7
    Conserved Domains (1) summary
    cd00213
    Location:456
    S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
  2. NM_001366407.1NP_001353336.1  protein S100-A2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    BX470102
    Consensus CDS
    CCDS91058.1
    UniProtKB/TrEMBL
    R4GN49
    Related
    ENSP00000473489.1, ENST00000497140.5
    Conserved Domains (1) summary
    cd00213
    Location:157
    S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
  3. NM_005978.4NP_005969.2  protein S100-A2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BX470102
    Consensus CDS
    CCDS1044.2
    UniProtKB/Swiss-Prot
    O00266, P29034, Q3KRB9, Q5RHS8, Q9BU83
    Related
    ENSP00000357697.4, ENST00000368708.9
    Conserved Domains (1) summary
    cd00213
    Location:491
    S-100; S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    153561108..153565844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427373.1XP_047283329.1  protein S100-A2 isoform X1

    UniProtKB/TrEMBL
    A6NDF0, Q5RHS7
    Related
    ENSP00000357696.5, ENST00000368707.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    152698363..152703111 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338109.1XP_054194084.1  protein S100-A2 isoform X1

    UniProtKB/TrEMBL
    A6NDF0, Q5RHS7