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BDNF brain derived neurotrophic factor [ Homo sapiens (human) ]

Gene ID: 627, updated on 6-Dec-2016
Official Symbol
BDNFprovided by HGNC
Official Full Name
brain derived neurotrophic factorprovided by HGNC
Primary source
HGNC:HGNC:1033
See related
Ensembl:ENSG00000176697 MIM:113505; Vega:OTTHUMG00000178797
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANON2; BULN2
Summary
This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]
Orthologs
Location:
11p14.1
Exon count:
12
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (27654893..27722058, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (27676440..27743605, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene BDNF antisense RNA Neighboring gene ribosomal protein S25 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 678 Neighboring gene chromobox 3 pseudogene 1 Neighboring gene heat shock protein 90 alpha family class A member 2, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Bulimia nervosa 1
MedGen: C1843776 OMIM: 607499 GeneReviews: Not available
Compare labs
Bulimia nervosa 2
MedGen: C1853220 OMIM: 610269 GeneReviews: Not available
Compare labs
Congenital central hypoventilation Compare labs
Obsessive-compulsive disorder
MedGen: C1834037 OMIM: 164230 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
NHGRI GWA Catalog
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.
NHGRI GWA Catalog
Genome wide association study identifies KCNMA1 contributing to human obesity.
NHGRI GWA Catalog
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
NHGRI GWA Catalog
Genome-wide meta-analyses identify multiple loci associated with smoking behavior.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Co-exposure of human fetal neurons to brain-derived neurotrophic factor (BDNF) and HIV-1 gp120 leads to a dose-dependent increase in BDNF-induced somatostatin (SRIF) production PubMed
Tat tat The gene expression of brain-derived neurotrophic factor is significantly upregulated in both clade B and clade C Tat treated SK-N-MC cells PubMed
tat Human BDNF is protective to neuroblastoma cells exposed to HIV-1 Tat PubMed
tat HIV-1 Tat increases proapoptotic proBDNF and decreases the mature BDNF protein in hippocampal neurons PubMed

Go to the HIV-1, Human Interaction Database

  • Alcoholism, organism-specific biosystem (from KEGG)
    Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • Alcoholism, conserved biosystem (from KEGG)
    Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • BDNF-TrkB Signaling, organism-specific biosystem (from WikiPathways)
    BDNF-TrkB Signaling, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is an important neurotrophin for the regulation of synaptic activity. BDNF-TrkB signaling, TrkB being the receptor of BDNF, is involved in transcription, tran...
  • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
    Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
  • Cocaine addiction, organism-specific biosystem (from KEGG)
    Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
  • Cocaine addiction, conserved biosystem (from KEGG)
    Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
  • ERK Pathway in Huntington's Disease, organism-specific biosystem (from WikiPathways)
    ERK Pathway in Huntington's Disease, organism-specific biosystemThis ERK pathway is implicated in Huntington's Disease. The ligands BDNF, EGF, and Glu bind to their respective receptors (TrkB, EGFR, mGluR) and start a signal transduction pathway starting with RAS...
  • Follicle Stimulating Hormone (FSH) signaling pathway, organism-specific biosystem (from WikiPathways)
    Follicle Stimulating Hormone (FSH) signaling pathway, organism-specific biosystemThe Follicle Stimulating Hormone (FSH) is an anterior pituitary gonadotropin belonging to the family of glycoprotein hormones that includes thyroid stimulating hormone (TSH), Leutinizing Hormone (LH)...
  • Huntington's disease, organism-specific biosystem (from KEGG)
    Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Huntington's disease, conserved biosystem (from KEGG)
    Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
  • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MECP2 and Associated Rett Syndrome, organism-specific biosystem (from WikiPathways)
    MECP2 and Associated Rett Syndrome, organism-specific biosystemMecp2 is in many mammals an important regulator of neuronal function and development. It affects all cell types, especially neurons but also astrocytes, oligodendrocytes, and glial cells. Mecp2 plays...
  • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
    Neurotrophic factor-mediated Trk receptor signaling
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
  • Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • p75(NTR)-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
    p75(NTR)-mediated signaling, organism-specific biosystem
    p75(NTR)-mediated signaling
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC34632

Gene Ontology Provided by GOA

Function Evidence Code Pubs
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
neurotrophin TRKB receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
brain-derived neurotrophic factor
Names
abrineurin
neurotrophin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011794.1 RefSeqGene

    Range
    5001..72164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001143805.1NP_001137277.1  brain-derived neurotrophic factor isoform a preproprotein

    See identical proteins and their annotated locations for NP_001137277.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), also known as IIa or BDNF2A, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF674517
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    UniProtKB/TrEMBL
    A0A0E3SU01
    Related
    ENSP00000432035, OTTHUMP00000232006, ENST00000525950, OTTHUMT00000388086
    Conserved Domains (1) summary
    smart00140
    Location:133240
    NGF; Nerve growth factor (NGF or beta-NGF)
  2. NM_001143806.1NP_001137278.1  brain-derived neurotrophic factor isoform a preproprotein

    See identical proteins and their annotated locations for NP_001137278.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), also known as IIb or BDNF2B, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF674518
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    UniProtKB/TrEMBL
    A0A0E3SU01
    Related
    ENSP00000379302, OTTHUMP00000232022, ENST00000395978, OTTHUMT00000388105
    Conserved Domains (1) summary
    smart00140
    Location:133240
    NGF; Nerve growth factor (NGF or beta-NGF)
  3. NM_001143807.1NP_001137279.1  brain-derived neurotrophic factor isoform a preproprotein

    See identical proteins and their annotated locations for NP_001137279.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), also known as III or BDNF3, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF674520
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    UniProtKB/TrEMBL
    A0A0E3SU01
    Related
    ENSP00000435805, OTTHUMP00000232021, ENST00000532997, OTTHUMT00000388104
    Conserved Domains (1) summary
    smart00140
    Location:133240
    NGF; Nerve growth factor (NGF or beta-NGF)
  4. NM_001143808.1NP_001137280.1  brain-derived neurotrophic factor isoform a preproprotein

    See identical proteins and their annotated locations for NP_001137280.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), also known as Va, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF689011
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    UniProtKB/TrEMBL
    A0A0E3SU01
    Related
    ENSP00000379307, OTTHUMP00000232018, ENST00000395983, OTTHUMT00000388101
    Conserved Domains (1) summary
    smart00140
    Location:133240
    NGF; Nerve growth factor (NGF or beta-NGF)
  5. NM_001143809.1NP_001137281.1  brain-derived neurotrophic factor isoform d

    See identical proteins and their annotated locations for NP_001137281.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), also known as Vb, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (d) contains a longer N-terminus and lacks a predicted signal peptide compared to isoform a.
    Source sequence(s)
    EF689012
    UniProtKB/Swiss-Prot
    P23560
    Conserved Domains (1) summary
    smart00140
    Location:162269
    NGF; Nerve growth factor (NGF or beta-NGF)
  6. NM_001143810.1NP_001137282.1  brain-derived neurotrophic factor isoform e

    See identical proteins and their annotated locations for NP_001137282.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), also known as V-VIII, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (e) contains a longer N-terminus and lacks a predicted signal peptide compared to isoform a.
    Source sequence(s)
    EF689019
    Consensus CDS
    CCDS44558.1
    UniProtKB/Swiss-Prot
    P23560
    Related
    ENSP00000414303, OTTHUMP00000232019, ENST00000438929, OTTHUMT00000388102
    Conserved Domains (1) summary
    smart00140
    Location:215322
    NGF; Nerve growth factor (NGF or beta-NGF)
  7. NM_001143811.1NP_001137283.1  brain-derived neurotrophic factor isoform a preproprotein

    See identical proteins and their annotated locations for NP_001137283.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), also known as V-VIII-VIIIh, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF689020
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    UniProtKB/TrEMBL
    A0A0E3SU01
    Related
    ENSP00000389564, ENST00000420794
    Conserved Domains (1) summary
    smart00140
    Location:133240
    NGF; Nerve growth factor (NGF or beta-NGF)
  8. NM_001143812.1NP_001137284.1  brain-derived neurotrophic factor isoform a preproprotein

    See identical proteins and their annotated locations for NP_001137284.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), also known as Vh, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    CX751420, EF689013
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    UniProtKB/TrEMBL
    A0A0E3SU01
    Related
    ENSP00000435564, OTTHUMP00000232016, ENST00000530861, OTTHUMT00000388099
    Conserved Domains (1) summary
    smart00140
    Location:133240
    NGF; Nerve growth factor (NGF or beta-NGF)
  9. NM_001143813.1NP_001137285.1  brain-derived neurotrophic factor isoform a preproprotein

    See identical proteins and their annotated locations for NP_001137285.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), also known as VIa, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF689014
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    UniProtKB/TrEMBL
    A0A0E3SU01
    Related
    ENSP00000432376, OTTHUMP00000232015, ENST00000533246, OTTHUMT00000388098
    Conserved Domains (1) summary
    smart00140
    Location:133240
    NGF; Nerve growth factor (NGF or beta-NGF)
  10. NM_001143814.1NP_001137286.1  brain-derived neurotrophic factor isoform a preproprotein

    See identical proteins and their annotated locations for NP_001137286.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), also known as VIb-IXbd, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF689016
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    UniProtKB/TrEMBL
    A0A0E3SU01
    Related
    ENSP00000400502, OTTHUMP00000232014, ENST00000418212, OTTHUMT00000388097
    Conserved Domains (1) summary
    smart00140
    Location:133240
    NGF; Nerve growth factor (NGF or beta-NGF)
  11. NM_001143816.1NP_001137288.1  brain-derived neurotrophic factor isoform a preproprotein

    See identical proteins and their annotated locations for NP_001137288.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), also known as IXabd, differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF689010
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    UniProtKB/TrEMBL
    A0A0E3SU01
    Related
    ENSP00000389345, OTTHUMP00000232039, ENST00000439476, OTTHUMT00000388134
    Conserved Domains (1) summary
    smart00140
    Location:133240
    NGF; Nerve growth factor (NGF or beta-NGF)
  12. NM_001709.4NP_001700.2  brain-derived neurotrophic factor isoform a preproprotein

    See identical proteins and their annotated locations for NP_001700.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as VIb or BDNF5, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF689015
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    UniProtKB/TrEMBL
    A0A0E3SU01
    Related
    ENSP00000349084, OTTHUMP00000232013, ENST00000356660, OTTHUMT00000388096
    Conserved Domains (1) summary
    smart00140
    Location:133240
    NGF; Nerve growth factor (NGF or beta-NGF)
  13. NM_170731.4NP_733927.1  brain-derived neurotrophic factor isoform b precursor

    See identical proteins and their annotated locations for NP_733927.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as I, BDNF1, or 1-5, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) contains a longer N-terminus compared to isoform a. This isoform (b) may undergo proteolytic processing similar to isoform a.
    Source sequence(s)
    EF689021
    Consensus CDS
    CCDS7865.1
    UniProtKB/Swiss-Prot
    P23560
    Related
    ENSP00000320002, OTTHUMP00000232043, ENST00000314915, OTTHUMT00000388138
    Conserved Domains (1) summary
    smart00140
    Location:141248
    NGF; Nerve growth factor (NGF or beta-NGF)
  14. NM_170732.4NP_733928.1  brain-derived neurotrophic factor isoform a preproprotein

    See identical proteins and their annotated locations for NP_733928.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as IIc, BDNF2C, or 2-5, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF674519
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    UniProtKB/TrEMBL
    A0A0E3SU01
    Related
    ENSP00000379305, OTTHUMP00000232005, ENST00000395981, OTTHUMT00000388085
    Conserved Domains (1) summary
    smart00140
    Location:133240
    NGF; Nerve growth factor (NGF or beta-NGF)
  15. NM_170733.3NP_733929.1  brain-derived neurotrophic factor isoform a preproprotein

    See identical proteins and their annotated locations for NP_733929.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as IV, BDNF4, or 3-5, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF674521
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    UniProtKB/TrEMBL
    A0A0E3SU01
    Related
    ENSP00000379304, ENST00000395980
    Conserved Domains (1) summary
    smart00140
    Location:133240
    NGF; Nerve growth factor (NGF or beta-NGF)
  16. NM_170734.3NP_733930.1  brain-derived neurotrophic factor isoform c

    See identical proteins and their annotated locations for NP_733930.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also known as VIIb, BDNF6B, or 4I-5, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) contains a longer N-terminus and lacks a predicted signal peptide compared to isoform a.
    Source sequence(s)
    EF689018
    Consensus CDS
    CCDS41628.1
    UniProtKB/Swiss-Prot
    P23560
    Related
    ENSP00000379309, OTTHUMP00000232041, ENST00000395986, OTTHUMT00000388136
    Conserved Domains (1) summary
    smart00140
    Location:148255
    NGF; Nerve growth factor (NGF or beta-NGF)
  17. NM_170735.5NP_733931.1  brain-derived neurotrophic factor isoform a preproprotein

    See identical proteins and their annotated locations for NP_733931.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as IX, represents the longest transcript. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
    Source sequence(s)
    EF689009
    Consensus CDS
    CCDS7866.1
    UniProtKB/Swiss-Prot
    P23560
    UniProtKB/TrEMBL
    A0A0E3SU01
    Related
    ENSP00000437138, OTTHUMP00000232040, ENST00000525528, OTTHUMT00000388135
    Conserved Domains (1) summary
    smart00140
    Location:133240
    NGF; Nerve growth factor (NGF or beta-NGF)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

    Range
    27654893..27722058 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520280.2XP_011518582.1  

    See identical proteins and their annotated locations for XP_011518582.1

    UniProtKB/Swiss-Prot
    P23560
    Conserved Domains (1) summary
    smart00140
    Location:215322
    NGF; Nerve growth factor (NGF or beta-NGF)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    27675184..27742527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001143815.1: Suppressed sequence

    Description
    NM_001143815.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript, which contains non-consensus splice sites in the 5' UTR.
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