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RYK receptor like tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 6259, updated on 21-Dec-2019

Summary

Official Symbol
RYKprovided by HGNC
Official Full Name
receptor like tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:10481
See related
Ensembl:ENSG00000163785 MIM:600524
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JTK5; RYK1; JTK5A; D3S3195
Summary
The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in ovary (RPKM 32.1), testis (RPKM 26.7) and 25 other tissues See more
Orthologs

Genomic context

See RYK in Genome Data Viewer
Location:
3q22.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (134157133..134250834, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (133875978..133969586, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374117 Neighboring gene long intergenic non-protein coding RNA 2000 Neighboring gene high mobility group box 3 pseudogene 14 Neighboring gene Sharpr-MPRA regulatory region 4898 Neighboring gene uncharacterized LOC105374118 Neighboring gene long intergenic non-protein coding RNA 2004

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of RYK PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Wnt-activated receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Wnt-protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Wnt-protein binding NAS
Non-traceable Author Statement
more info
PubMed 
coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway TAS
Traceable Author Statement
more info
PubMed 
frizzled binding ISS
Inferred from Sequence or Structural Similarity
more info
 
frizzled binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation TAS
Traceable Author Statement
more info
PubMed 
axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
axon guidance NAS
Non-traceable Author Statement
more info
PubMed 
axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
axonogenesis TAS
Traceable Author Statement
more info
PubMed 
canonical Wnt signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
cell proliferation in midbrain ISS
Inferred from Sequence or Structural Similarity
more info
 
chemorepulsion of dopaminergic neuron axon ISS
Inferred from Sequence or Structural Similarity
more info
 
commissural neuron axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
corpus callosum development ISS
Inferred from Sequence or Structural Similarity
more info
 
midbrain dopaminergic neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of axon extension involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 
nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurogenesis NAS
Non-traceable Author Statement
more info
PubMed 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
non-canonical Wnt signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
planar cell polarity pathway involved in axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
NOT protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
synapse assembly NAS
Non-traceable Author Statement
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tyrosine-protein kinase RYK
Names
JTK5A protein tyrosine kinase
hydroxyaryl-protein kinase
NP_001005861.1
NP_002949.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032937.1 RefSeqGene

    Range
    5001..98611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001005861.2NP_001005861.1  tyrosine-protein kinase RYK isoform 1 precursor

    See identical proteins and their annotated locations for NP_001005861.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB209405, BC021700, CN309980, X69970
    Consensus CDS
    CCDS75016.1
    UniProtKB/Swiss-Prot
    P34925
    UniProtKB/TrEMBL
    A0A087WUK1, Q59FQ5, Q8WTZ8
    Related
    ENSP00000478721.1, ENST00000620660.4
    Conserved Domains (3) summary
    smart00469
    Location:63196
    WIF; Wnt-inhibitory factor-1 like domain
    cd05043
    Location:326606
    PTK_Ryk; Pseudokinase domain of Ryk (Receptor related to tyrosine kinase)
    pfam07714
    Location:333599
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_002958.3NP_002949.2  tyrosine-protein kinase RYK isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AB209405, BC021700, CN309980, X69970
    Consensus CDS
    CCDS77820.1
    UniProtKB/Swiss-Prot
    P34925
    UniProtKB/TrEMBL
    A0A096LNL3, Q59FQ5, Q8WTZ8
    Related
    ENSP00000485095.1, ENST00000623711.3
    Conserved Domains (2) summary
    smart00469
    Location:63196
    WIF; Wnt-inhibitory factor-1 like domain
    cd05043
    Location:323603
    PTK_Ryk; Pseudokinase domain of Ryk (Receptor related to tyrosine kinase)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    134157133..134250834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_924160.2 RNA Sequence

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