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RTN2 reticulon 2 [ Homo sapiens (human) ]

Gene ID: 6253, updated on 7-Aug-2020

Summary

Official Symbol
RTN2provided by HGNC
Official Full Name
reticulon 2provided by HGNC
Primary source
HGNC:HGNC:10468
See related
Ensembl:ENSG00000125744 MIM:603183
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NSP2; NSPL1; NSPLI; SPG12
Summary
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Reticulon proteins also play an important role in the replication of positive-strand RNA (ssRNA) viruses. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. [provided by RefSeq, Aug 2020]
Expression
Broad expression in brain (RPKM 9.6), placenta (RPKM 7.1) and 22 other tissues See more
Orthologs

Genomic context

See RTN2 in Genome Data Viewer
Location:
19q13.32
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (45485294..45497047, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45988546..46000313, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ERCC excision repair 1, endonuclease non-catalytic subunit Neighboring gene microRNA 6088 Neighboring gene FosB proto-oncogene, AP-1 transcription factor subunit Neighboring gene uncharacterized LOC107985314 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1N (putative) Neighboring gene vasodilator stimulated phosphoprotein Neighboring gene uncharacterized LOC107985315

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of reticulon 2 (RTN2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
intracellular protein transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
T-tubule IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
integral component of endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
PubMed 
terminal cisterna IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
reticulon-2
Names
NSP-like protein 1
NSP-like protein I
neuroendocrine-specific protein-like I

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032157.1 RefSeqGene

    Range
    5007..16760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005619.5NP_005610.1  reticulon-2 isoform A

    See identical proteins and their annotated locations for NP_005610.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (A).
    Source sequence(s)
    AF004222, BC073874, BK001687
    Consensus CDS
    CCDS12665.1
    UniProtKB/Swiss-Prot
    O75298
    UniProtKB/TrEMBL
    A8K7F2, Q6GMT0
    Related
    ENSP00000245923.3, ENST00000245923.9
    Conserved Domains (1) summary
    pfam02453
    Location:345509
    Reticulon; Reticulon
  2. NM_206900.3NP_996783.1  reticulon-2 isoform B

    See identical proteins and their annotated locations for NP_996783.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (B), that is missing an internal segment compared to isoform A.
    Source sequence(s)
    BC073874, BK001688
    Consensus CDS
    CCDS12666.1
    UniProtKB/Swiss-Prot
    O75298
    UniProtKB/TrEMBL
    A8K7F2, Q6GMT0
    Related
    ENSP00000345127.3, ENST00000344680.8
    Conserved Domains (1) summary
    pfam02453
    Location:272436
    Reticulon; Reticulon
  3. NM_206901.3NP_996784.1  reticulon-2 isoform C

    See identical proteins and their annotated locations for NP_996784.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (C) has a shorter N-terminus when compared to isoform A, and is presumably transcribed from an internal promoter.
    Source sequence(s)
    AC138534, AF004224, DA898294
    Consensus CDS
    CCDS46114.1
    UniProtKB/Swiss-Prot
    O75298
    UniProtKB/TrEMBL
    A8K7F2
    Related
    ENSP00000398178.1, ENST00000430715.6
    Conserved Domains (1) summary
    pfam02453
    Location:5169
    Reticulon; Reticulon

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    45485294..45497047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_206902.1: Suppressed sequence

    Description
    NM_206902.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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