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RSU1 Ras suppressor protein 1 [ Homo sapiens (human) ]

Gene ID: 6251, updated on 4-Dec-2022

Summary

Official Symbol
RSU1provided by HGNC
Official Full Name
Ras suppressor protein 1provided by HGNC
Primary source
HGNC:HGNC:10464
See related
Ensembl:ENSG00000148484 MIM:179555; AllianceGenome:HGNC:10464
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RSP-1
Summary
This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 25.2), endometrium (RPKM 23.1) and 25 other tissues See more
Orthologs
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Genomic context

See RSU1 in Genome Data Viewer
Location:
10p13
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (16590611..16817424, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (16609081..16835881, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (16632610..16859423, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene phosphotriesterase related Neighboring gene RNA, U2 small nuclear 18, pseudogene Neighboring gene complement C1q like 3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:16639108-16640307 Neighboring gene uncharacterized LOC124902385 Neighboring gene uncharacterized LOC124902384 Neighboring gene uncharacterized LOC105376435 Neighboring gene cubilin Neighboring gene GATA motif-containing MPRA enhancer 283

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
CUBN is a gene locus for albuminuria.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31034

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in regulation of cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ras suppressor protein 1
Names
rsu-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012425.4NP_036557.1  ras suppressor protein 1 isoform 1

    See identical proteins and their annotated locations for NP_036557.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC073367, AK055596, BC005993, BG400752, BX647733
    Consensus CDS
    CCDS7112.1
    UniProtKB/Swiss-Prot
    Q15404, Q6FI17
    Related
    ENSP00000339521.5, ENST00000345264.10
    Conserved Domains (2) summary
    PLN00113
    Location:34200
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:1941
    LRR_RI; leucine-rich repeat [structural motif]
  2. NM_152724.3NP_689937.2  ras suppressor protein 1 isoform 2

    See identical proteins and their annotated locations for NP_689937.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 5' UTR and 5' coding region and uses a downstream start codon, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus, compared to isoform 1. This transcript is supported by multiple ESTs, but the predicted ORF has not yet been experimentally confirmed.
    Source sequence(s)
    AC073367, AK055596, BG400752, BX647733
    Consensus CDS
    CCDS31157.1
    UniProtKB/Swiss-Prot
    Q15404
    Related
    ENSP00000473588.1, ENST00000602389.1
    Conserved Domains (3) summary
    cd00116
    Location:27140
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:1234
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:3493
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    16590611..16817424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425617.1XP_047281573.1  ras suppressor protein 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    16609081..16835881 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)