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Lipt1 lipoyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 623661, updated on 30-Apr-2024

Summary

Official Symbol
Lipt1provided by MGI
Official Full Name
lipoyltransferase 1provided by MGI
Primary source
MGI:MGI:3645211
See related
Ensembl:ENSMUSG00000037216 AllianceGenome:MGI:3645211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG623661
Summary
Predicted to enable lipoyltransferase activity. Predicted to be involved in protein lipoylation. Located in mitochondrion. Is expressed in embryo. Orthologous to human LIPT1 (lipoyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

Location:
1 B; 1 16.13 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (37910819..37915309)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (37871738..37876228)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene capping protein inhibiting regulator of actin like Neighboring gene predicted gene, 39628 Neighboring gene testis specific 10 Neighboring gene STARR-seq mESC enhancer starr_00684 Neighboring gene STARR-positive B cell enhancer mm9_chr1:37921599-37921900 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:37922129-37922238 Neighboring gene MIT, microtubule interacting and transport, domain containing 1 Neighboring gene mitochondrial ribosomal protein L30 Neighboring gene lysozyme G-like 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Clone Names

  • MGC28431

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein lipoylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
lipoyl amidotransferase LIPT1, mitochondrial
Names
lipoate biosynthesis protein
lipoate-protein ligase
lipoyl ligase
lipoyltransferase 1, mitochondrial
NP_001033007.2
NP_001363958.1
NP_001363959.1
NP_001363960.1
NP_001363961.1
NP_001363962.1
NP_001363963.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037918.4NP_001033007.2  lipoyl amidotransferase LIPT1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001033007.2

    Status: VALIDATED

    Source sequence(s)
    AC119189, AK048005
    Consensus CDS
    CCDS14895.1
    UniProtKB/Swiss-Prot
    Q8VCM4
    UniProtKB/TrEMBL
    Q8C894
    Related
    ENSMUSP00000038739.4, ENSMUST00000041621.5
    Conserved Domains (1) summary
    cd16443
    Location:33235
    LplA; lipoate-protein ligase
  2. NM_001377029.1NP_001363958.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC119189
    UniProtKB/Swiss-Prot
    Q8VCM4
    UniProtKB/TrEMBL
    Q8C894
    Conserved Domains (1) summary
    cd16443
    Location:33235
    LplA; lipoate-protein ligase
  3. NM_001377030.1NP_001363959.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC119189
    UniProtKB/Swiss-Prot
    Q8VCM4
    UniProtKB/TrEMBL
    Q8C894
    Conserved Domains (1) summary
    cd16443
    Location:33235
    LplA; lipoate-protein ligase
  4. NM_001377031.1NP_001363960.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC119189
    UniProtKB/Swiss-Prot
    Q8VCM4
    UniProtKB/TrEMBL
    Q8C894
    Conserved Domains (1) summary
    cd16443
    Location:33235
    LplA; lipoate-protein ligase
  5. NM_001377032.1NP_001363961.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC119189
    UniProtKB/Swiss-Prot
    Q8VCM4
    UniProtKB/TrEMBL
    Q8C894
    Conserved Domains (1) summary
    cd16443
    Location:33235
    LplA; lipoate-protein ligase
  6. NM_001377033.1NP_001363962.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC119189
    UniProtKB/Swiss-Prot
    Q8VCM4
    UniProtKB/TrEMBL
    Q8C894
    Conserved Domains (1) summary
    cd16443
    Location:33235
    LplA; lipoate-protein ligase
  7. NM_001377034.1NP_001363963.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC119189, BQ442858
    UniProtKB/Swiss-Prot
    Q8VCM4
    UniProtKB/TrEMBL
    Q8C894
    Conserved Domains (1) summary
    cd16443
    Location:33235
    LplA; lipoate-protein ligase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    37910819..37915309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)