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RPS23 ribosomal protein S23 [ Homo sapiens (human) ]

Gene ID: 6228, updated on 9-Feb-2020

Summary

Official Symbol
RPS23provided by HGNC
Official Full Name
ribosomal protein S23provided by HGNC
Primary source
HGNC:HGNC:10410
See related
Ensembl:ENSG00000186468 MIM:603683
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S23; BTDD; uS12; MABAS; MCINS; PAMAS
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12P family of ribosomal proteins. It is located in the cytoplasm. The protein shares significant amino acid similarity with S. cerevisiae ribosomal protein S28. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 288.5), bone marrow (RPKM 141.7) and 25 other tissues See more
Orthologs

Genomic context

See RPS23 in Genome Data Viewer
Location:
5q14.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (82273320..82278354, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (81569139..81574235, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1432 Neighboring gene autophagy related 10 Neighboring gene RNA, 7SL, cytoplasmic 378, pseudogene Neighboring gene ATPase H+ transporting accessory protein 1 like Neighboring gene uncharacterized LOC105379050

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, ribosomal protein S23 (RPS23), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human ribosomal protein S23 (RPS23) at amino acid residues 92-93 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35016

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
cytoplasmic translation IDA
Inferred from Direct Assay
more info
PubMed 
maintenance of translational fidelity IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
stress granule assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation IC
Inferred by Curator
more info
PubMed 
translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
cytosolic small ribosomal subunit HDA PubMed 
cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
polysomal ribosome IDA
Inferred from Direct Assay
more info
PubMed 
ribosome NAS
Non-traceable Author Statement
more info
PubMed 
rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
40S ribosomal protein S23
Names
homolog of yeast ribosomal protein S28
small ribosomal subunit protein uS12

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025.5NP_001016.1  40S ribosomal protein S23

    See identical proteins and their annotated locations for NP_001016.1

    Status: REVIEWED

    Source sequence(s)
    AC010598, AI955885, BU594771, D14530
    Consensus CDS
    CCDS47241.1
    UniProtKB/Swiss-Prot
    P62266
    UniProtKB/TrEMBL
    A8K517
    Related
    ENSP00000296674.8, ENST00000296674.13
    Conserved Domains (1) summary
    PTZ00067
    Location:1143
    PTZ00067; 40S ribosomal S23; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    82273320..82278354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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