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RPS21 ribosomal protein S21 [ Homo sapiens (human) ]

Gene ID: 6227, updated on 10-Oct-2020

Summary

Official Symbol
RPS21provided by HGNC
Official Full Name
ribosomal protein S21provided by HGNC
Primary source
HGNC:HGNC:10409
See related
Ensembl:ENSG00000171858 MIM:180477
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S21; HLDF
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S21E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants that encode different protein isoforms have been described, but their existence has not been verified. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 530.1), bone marrow (RPKM 407.8) and 25 other tissues See more
Orthologs

Genomic context

See RPS21 in Genome Data Viewer
Location:
20q13.33
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (62386275..62388520)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (60962121..60963576)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene laminin subunit alpha 5 Neighboring gene LAMA5 antisense RNA 1 Neighboring gene uncharacterized LOC105372708 Neighboring gene Cdk5 and Abl enzyme substrate 2 Neighboring gene uncharacterized LOC105372709 Neighboring gene RBBP8 N-terminal like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic small ribosomal subunit HDA PubMed 
cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
polysomal ribosome IDA
Inferred from Direct Assay
more info
PubMed 
rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
small ribosomal subunit HDA PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
40S ribosomal protein S21
Names
8.2 kDa differentiation factor
human leukemia differentiation factor
small ribosomal subunit protein eS21

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024.4NP_001015.1  40S ribosomal protein S21

    See identical proteins and their annotated locations for NP_001015.1

    Status: REVIEWED

    Source sequence(s)
    BM840443, CF124568, L04483
    Consensus CDS
    CCDS13497.1
    UniProtKB/Swiss-Prot
    P63220
    UniProtKB/TrEMBL
    Q6FGH5
    Related
    ENSP00000345957.3, ENST00000343986.9
    Conserved Domains (1) summary
    pfam01249
    Location:180
    Ribosomal_S21e; Ribosomal protein S21e

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    62386275..62388520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451959.1XP_024307727.1  40S ribosomal protein S21 isoform X1

    Conserved Domains (1) summary
    pfam01249
    Location:270331
    Ribosomal_S21e; Ribosomal protein S21e
  2. XM_024451960.1XP_024307728.1  40S ribosomal protein S21 isoform X2

    Conserved Domains (1) summary
    pfam01249
    Location:270325
    Ribosomal_S21e; Ribosomal protein S21e

RNA

  1. XR_002958499.1 RNA Sequence

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