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RPS20 ribosomal protein S20 [ Homo sapiens (human) ]

Gene ID: 6224, updated on 3-Jun-2018
Official Symbol
RPS20provided by HGNC
Official Full Name
ribosomal protein S20provided by HGNC
Primary source
HGNC:HGNC:10405
See related
Ensembl:ENSG00000008988 MIM:603682; Vega:OTTHUMG00000164297
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S20; uS10
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10P family of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the small nucleolar RNA gene U54, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2009]
Expression
Ubiquitous expression in ovary (RPKM 727.4), fat (RPKM 436.0) and 25 other tissues See more
Orthologs
See RPS20 in Genome Data Viewer
Location:
8q12.1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (56068180..56074581, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (56980739..56987140, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 323, pseudogene Neighboring gene proteasome 26S subunit, ATPase, 6 pseudogene 1 Neighboring gene small nucleolar RNA, C/D box 54 Neighboring gene competing endogenous lncRNA 3 for miR-645 Neighboring gene nucleophosmin 1 pseudogene 21

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef immunocomplexes analyzed by mass spectrometry reveal that ribosomal protein S20 (RPS20) is a Nef-binding protein in Jurkat cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ27451, MGC102930

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome HDA PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation IC
Inferred by Curator
more info
PubMed 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic small ribosomal subunit HDA PubMed 
cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
40S ribosomal protein S20
Names
small ribosomal subunit protein uS10

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042872.1 RefSeqGene

    Range
    5001..11402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023.3NP_001014.1  40S ribosomal protein S20 isoform 2

    See identical proteins and their annotated locations for NP_001014.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC007507, BQ064297, CB138358
    Consensus CDS
    CCDS6163.1
    UniProtKB/Swiss-Prot
    P60866
    Related
    ENSP00000009589.3, OTTHUMP00000226397, ENST00000009589.7, OTTHUMT00000378163
    Conserved Domains (1) summary
    cl00314
    Location:16116
    Ribosomal_S10; Ribosomal protein S10p/S20e
  2. NM_001146227.1NP_001139699.1  40S ribosomal protein S20 isoform 1

    See identical proteins and their annotated locations for NP_001139699.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK301342, CB138358, CD671362
    Consensus CDS
    CCDS55231.1
    UniProtKB/Swiss-Prot
    P60866
    Related
    ENSP00000429374.1, OTTHUMP00000226396, ENST00000519807.5, OTTHUMT00000378162
    Conserved Domains (1) summary
    cl00314
    Location:16112
    Ribosomal_S10; Ribosomal protein S10p/S20e

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    56068180..56074581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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