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RPS18 ribosomal protein S18 [ Homo sapiens (human) ]

Gene ID: 6222, updated on 9-Dec-2024

Summary

Official Symbol
RPS18provided by HGNC
Official Full Name
ribosomal protein S18provided by HGNC
Primary source
HGNC:HGNC:10401
See related
Ensembl:ENSG00000231500 MIM:180473; AllianceGenome:HGNC:10401
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KE3; S18; HKE3; KE-3; uS13; D6S218E
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 1981.9), bone marrow (RPKM 1363.6) and 25 other tissues See more
Orthologs
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Genomic context

See RPS18 in Genome Data Viewer
Location:
6p21.32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (33272075..33276511)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (33093437..33097873)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (33239852..33244288)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375022 Neighboring gene HLA complex group 25 Neighboring gene VPS52 subunit of GARP complex Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33244298-33245030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33245765-33246496 Neighboring gene beta-1,3-galactosyltransferase 4 Neighboring gene WD repeat domain 46 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33255009-33255542 Neighboring gene microRNA 6873

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC117351, MGC126835, MGC126837

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in translation IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
small ribosomal subunit protein uS13
Names
40S ribosomal protein S18
rhabdomyosarcoma antigen MU-RMS-40.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022551.3NP_072045.1  small ribosomal subunit protein uS13

    See identical proteins and their annotated locations for NP_072045.1

    Status: REVIEWED

    Source sequence(s)
    AL645940, AL662820
    Consensus CDS
    CCDS4771.1
    UniProtKB/Swiss-Prot
    P25232, P62269, Q5SUJ3, Q6IPF8
    Related
    ENSP00000393241.2, ENST00000439602.7
    Conserved Domains (1) summary
    PTZ00134
    Location:1152
    PTZ00134; 40S ribosomal protein S18; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    33272075..33276511
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    4683556..4687992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    4515589..4520025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    4708037..4712477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    4466492..4470931
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    4720756..4721414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    33093437..33097873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)