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Triml2 tripartite motif family-like 2 [ Mus musculus (house mouse) ]

Gene ID: 622117, updated on 13-Dec-2022

Summary

Official Symbol
Triml2provided by MGI
Official Full Name
tripartite motif family-like 2provided by MGI
Primary source
MGI:MGI:3642989
See related
Ensembl:ENSMUSG00000091490 AllianceGenome:MGI:3642989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tu4; EG622117
Summary
Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Acts upstream of or within response to retinoic acid. Predicted to be active in cytosol and nucleoplasm. Orthologous to human TRIML2 (tripartite motif family like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward placenta adult (RPKM 4.9) See more
Orthologs
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Genomic context

See Triml2 in Genome Data Viewer
Location:
8; 8 A4
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (43633500..43646921)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (43180463..43193884)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene tryptophanyl-tRNA synthetase pseudogene Neighboring gene tripartite motif family-like 1 Neighboring gene bromodomain adjacent to zinc finger domain, 2A pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene zinc finger protein 42

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable E3 ubiquitin-protein ligase TRIML2
NP_001153884.1
NP_001368858.1
XP_006509536.1
XP_017168415.1
XP_030099563.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160412.2NP_001153884.1  probable E3 ubiquitin-protein ligase TRIML2

    See identical proteins and their annotated locations for NP_001153884.1

    Status: VALIDATED

    Source sequence(s)
    AC142104
    Consensus CDS
    CCDS52546.1
    UniProtKB/TrEMBL
    E9PW10
    Related
    ENSMUSP00000148196.2, ENSMUST00000210136.2
    Conserved Domains (3) summary
    COG1196
    Location:55243
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13733
    Location:245418
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cl00034
    Location:1858
    Bbox_SF; B-box-type zinc finger superfamily
  2. NM_001381929.1NP_001368858.1  probable E3 ubiquitin-protein ligase TRIML2

    Status: VALIDATED

    Source sequence(s)
    AC142104
    UniProtKB/TrEMBL
    E9PW10
    Related
    ENSMUSP00000147371.2, ENSMUST00000209200.2
    Conserved Domains (3) summary
    COG1196
    Location:55243
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13733
    Location:245418
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cl00034
    Location:1858
    Bbox_SF; B-box-type zinc finger superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    43633500..43646921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312926.3XP_017168415.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X1

    UniProtKB/TrEMBL
    E9PW10
    Conserved Domains (3) summary
    COG1196
    Location:55243
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13733
    Location:245418
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
    cl00034
    Location:1858
    Bbox_SF; B-box-type zinc finger superfamily
  2. XM_030243703.1XP_030099563.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X3

    Conserved Domains (1) summary
    cl00034
    Location:1858
    Bbox_SF; B-box-type zinc finger superfamily
  3. XM_006509473.2XP_006509536.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X2

    Conserved Domains (1) summary
    cd13733
    Location:143316
    SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

RNA

  1. XR_001778460.2 RNA Sequence