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H2ac21 H2A clustered histone 21 [ Mus musculus (house mouse) ]

Gene ID: 621893, updated on 26-Sep-2022

Summary

Official Symbol
H2ac21provided by MGI
Official Full Name
H2A clustered histone 21provided by MGI
Primary source
MGI:MGI:2448314
See related
Ensembl:ENSMUSG00000063689 AllianceGenome:MGI:2448314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG621893; H2a-613a; Hist2h2ab
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Aug 2015]
Orthologs
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Genomic context

See H2ac21 in Genome Data Viewer
Location:
3; 3 F2.1
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96127201..96127670)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96219885..96220354)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene synaptic vesicle glycoprotein 2a Neighboring gene bolA-like 1 (E. coli) Neighboring gene H2A clustered histone 20 Neighboring gene H2B clustered histone 21

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
histone H2A type 2-B
Names
histone 2, H2ab
histone cluster 2, H2ab

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178213.6NP_835585.3  histone H2A type 2-B

    See identical proteins and their annotated locations for NP_835585.3

    Status: VALIDATED

    Source sequence(s)
    AC125099
    Consensus CDS
    CCDS38553.1
    UniProtKB/Swiss-Prot
    Q64522
    UniProtKB/TrEMBL
    A0A6P5PKT2
    Related
    ENSMUSP00000072858.5, ENSMUST00000073115.5
    Conserved Domains (1) summary
    cd00074
    Location:6120
    H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    96127201..96127670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)