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RPS16 ribosomal protein S16 [ Homo sapiens (human) ]

Gene ID: 6217, updated on 7-Oct-2018

Summary

Official Symbol
RPS16provided by HGNC
Official Full Name
ribosomal protein S16provided by HGNC
Primary source
HGNC:HGNC:10396
See related
Ensembl:ENSG00000105193 MIM:603675; Vega:OTTHUMG00000182972
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S16
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S9P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 933.9), lymph node (RPKM 484.0) and 25 other tissues See more
Orthologs

Genomic context

See RPS16 in Genome Data Viewer
Location:
19q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (39433137..39436020, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39923847..39926660, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene transfer RNA-Ile (TAT) 1-1 Neighboring gene pleckstrin homology and RhoGEF domain containing G2 Neighboring gene SPT5 homolog, DSIF elongation factor subunit Neighboring gene small nucleolar RNA, C/D box 175 Neighboring gene translocase of inner mitochondrial membrane 50

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with RPL27AP6 as demonstrated by proximity dependent biotinylation proteomics PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
liver regeneration IEA
Inferred from Electronic Annotation
more info
 
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
rRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosomal small subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
translation IC
Inferred by Curator
more info
PubMed 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
40S ribosomal protein S16
Names
small ribosomal subunit protein uS9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001020.5NP_001011.1  40S ribosomal protein S16 isoform 1

    See identical proteins and their annotated locations for NP_001011.1

    Status: REVIEWED

    Source sequence(s)
    AA890305, AC011500, AK315498
    Consensus CDS
    CCDS12535.1
    UniProtKB/Swiss-Prot
    P62249
    Related
    ENSP00000251453.2, OTTHUMP00000270594, ENST00000251453.7, OTTHUMT00000464511
    Conserved Domains (1) summary
    PLN00210
    Location:6146
    PLN00210; 40S ribosomal protein S16; Provisional
  2. NM_001321111.1NP_001308040.1  40S ribosomal protein S16 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AA890305, AC011500, BC095429
    Consensus CDS
    CCDS82349.1
    UniProtKB/TrEMBL
    M0R210
    Related
    ENSP00000472231.1, OTTHUMP00000270595, ENST00000601655.5, OTTHUMT00000464512
    Conserved Domains (1) summary
    PLN00210
    Location:6129
    PLN00210; 40S ribosomal protein S16; Provisional
  3. NM_001363860.1NP_001350789.1  40S ribosomal protein S16 isoform 3

    Status: REVIEWED

    Source sequence(s)
    BG340248, CB151553, CD249175
    Consensus CDS
    CCDS86768.1
    Conserved Domains (1) summary
    cl00334
    Location:686
    Ribosomal_S9; Ribosomal protein S9/S16

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    39433137..39436020 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259137.3XP_005259194.1  40S ribosomal protein S16 isoform X1

    UniProtKB/TrEMBL
    Q6IPX4
    Related
    ENSP00000367806.2, OTTHUMP00000270593, ENST00000339471.8
    Conserved Domains (1) summary
    cl00334
    Location:686
    Ribosomal_S9; Ribosomal protein S9/S16
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