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RPS15A ribosomal protein S15a [ Homo sapiens (human) ]

Gene ID: 6210, updated on 13-Jan-2020

Summary

Official Symbol
RPS15Aprovided by HGNC
Official Full Name
ribosomal protein S15aprovided by HGNC
Primary source
HGNC:HGNC:10389
See related
Ensembl:ENSG00000134419 MIM:603674
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S15a; DBA20
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 1052.3), bone marrow (RPKM 811.7) and 25 other tissues See more
Orthologs

Genomic context

See RPS15A in Genome Data Viewer
Location:
16p12.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (18781295..18790334, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (18794277..18801656, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene NODAL modulator 2 Neighboring gene Sharpr-MPRA regulatory region 10538 Neighboring gene ATP binding cassette subfamily C member 6 pseudogene 1 Neighboring gene ADP ribosylation factor like GTPase 6 interacting protein 1 Neighboring gene SMG1 nonsense mediated mRNA decay associated PI3K related kinase Neighboring gene putative uncharacterized protein encoded by LINC00269

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ27457, MGC111208

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome HDA PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
positive regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
response to virus IDA
Inferred from Direct Assay
more info
PubMed 
translation IC
Inferred by Curator
more info
PubMed 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
cytosolic small ribosomal subunit HDA PubMed 
cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
40S ribosomal protein S15a
Names
small ribosomal subunit protein uS8
up-regulated by HBV X protein
NP_001010.2
NP_001025180.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001019.5NP_001010.2  40S ribosomal protein S15a

    See identical proteins and their annotated locations for NP_001010.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is the longest transcript and utilizes an alternate splice site on the 5'-terminal exon, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC138811, BC001697, BF678907
    Consensus CDS
    CCDS10571.1
    UniProtKB/Swiss-Prot
    P62244
    UniProtKB/TrEMBL
    B2R4W8
    Related
    ENSP00000318646.4, ENST00000322989.8
    Conserved Domains (1) summary
    PTZ00158
    Location:1130
    PTZ00158; 40S ribosomal protein S15A; Provisional
  2. NM_001030009.2NP_001025180.1  40S ribosomal protein S15a

    See identical proteins and their annotated locations for NP_001025180.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant transcript and utilizes an alternate splice site on the 5'-terminal exon, compared to variant 2. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC138811, AK130967, BC030569
    Consensus CDS
    CCDS10571.1
    UniProtKB/Swiss-Prot
    P62244
    UniProtKB/TrEMBL
    B2R4W8
    Related
    ENSP00000457000.1, ENST00000563390.5
    Conserved Domains (1) summary
    PTZ00158
    Location:1130
    PTZ00158; 40S ribosomal protein S15A; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    18781295..18790334 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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