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RPS12 ribosomal protein S12 [ Homo sapiens (human) ]

Gene ID: 6206, updated on 11-Jun-2021

Summary

Official Symbol
RPS12provided by HGNC
Official Full Name
ribosomal protein S12provided by HGNC
Primary source
HGNC:HGNC:10385
See related
Ensembl:ENSG00000112306 MIM:603660
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S12
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 1633.0), bone marrow (RPKM 1134.0) and 25 other tissues See more
Orthologs
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Genomic context

See RPS12 in Genome Data Viewer
Location:
6q23.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (132814569..132817564)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (133135708..133138703)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 18 member B1 Neighboring gene uncharacterized LOC107986644 Neighboring gene small nucleolar RNA, C/D box 101 Neighboring gene small nucleolar RNA, C/D box 100 Neighboring gene small nucleolar RNA, H/ACA box 33 Neighboring gene uncharacterized LOC105378008 Neighboring gene high mobility group box 1 pseudogene 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study for diabetic nephropathy genes in African Americans.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

General protein information

Preferred Names
40S ribosomal protein S12
Names
small ribosomal subunit protein eS12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001016.4NP_001007.2  40S ribosomal protein S12

    See identical proteins and their annotated locations for NP_001007.2

    Status: REVIEWED

    Source sequence(s)
    BC095424, BQ276878
    Consensus CDS
    CCDS5164.1
    UniProtKB/Swiss-Prot
    P25398
    Related
    ENSP00000230050.3, ENST00000230050.4
    Conserved Domains (1) summary
    pfam01248
    Location:16111
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    132814569..132817564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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