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RPS6KB2 ribosomal protein S6 kinase B2 [ Homo sapiens (human) ]

Gene ID: 6199, updated on 24-Nov-2020

Summary

Official Symbol
RPS6KB2provided by HGNC
Official Full Name
ribosomal protein S6 kinase B2provided by HGNC
Primary source
HGNC:HGNC:10437
See related
Ensembl:ENSG00000175634 MIM:608939
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KLS; SRK; S6K2; S6KB; STK14B; S6KI(2); S6Kbeta; p70S6Kb; P70-beta; S6K-beta2; P70-beta-1; P70-beta-2; p70(S6K)-beta
Summary
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]
Expression
Ubiquitous expression in skin (RPKM 31.3), esophagus (RPKM 20.5) and 25 other tissues See more
Orthologs

Genomic context

See RPS6KB2 in Genome Data Viewer
Location:
11q13.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (67428475..67435408)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67195935..67202879)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 10C Neighboring gene carnosine synthase 1 Neighboring gene protein tyrosine phosphatase receptor type C associated protein Neighboring gene coronin 1B Neighboring gene G protein-coupled receptor 152 Neighboring gene calcium binding protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with p70S6Kb PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
peptide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
translation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ribosomal protein S6 kinase beta-2
Names
70 kDa ribosomal protein S6 kinase 2
P70S6K2
S6 kinase-related kinase
S6K-beta
S6K-beta-2
p70 S6 kinase beta
p70 S6K-beta
p70 S6KB
p70 ribosomal S6 kinase beta
p70-S6K 2
ribosomal protein S6 kinase, 70kDa, polypeptide 2
serine/threonine-protein kinase 14 beta
serine/threonine-protein kinase 14B
NP_003943.2
XP_005274221.1
XP_005274222.1
XP_006718718.1
XP_006718719.1
XP_006718720.1
XP_016873597.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003952.3NP_003943.2  ribosomal protein S6 kinase beta-2

    See identical proteins and their annotated locations for NP_003943.2

    Status: REVIEWED

    Source sequence(s)
    AB019245, AP003419, BX337895, BX538119
    Consensus CDS
    CCDS41677.1
    UniProtKB/Swiss-Prot
    Q9UBS0
    Related
    ENSP00000308413.5, ENST00000312629.10
    Conserved Domains (2) summary
    smart00220
    Location:67328
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05584
    Location:70392
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    67428475..67435408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274164.1XP_005274221.1  ribosomal protein S6 kinase beta-2 isoform X1

    Conserved Domains (2) summary
    COG0515
    Location:1331
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd05584
    Location:1295
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
  2. XM_005274165.5XP_005274222.1  ribosomal protein S6 kinase beta-2 isoform X2

    See identical proteins and their annotated locations for XP_005274222.1

    Conserved Domains (1) summary
    cl21453
    Location:1192
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006718656.3XP_006718719.1  ribosomal protein S6 kinase beta-2 isoform X2

    See identical proteins and their annotated locations for XP_006718719.1

    Conserved Domains (1) summary
    cl21453
    Location:1192
    PKc_like; Protein Kinases, catalytic domain
  4. XM_006718655.4XP_006718718.1  ribosomal protein S6 kinase beta-2 isoform X2

    See identical proteins and their annotated locations for XP_006718718.1

    Conserved Domains (1) summary
    cl21453
    Location:1192
    PKc_like; Protein Kinases, catalytic domain
  5. XM_017018108.2XP_016873597.1  ribosomal protein S6 kinase beta-2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1192
    PKc_like; Protein Kinases, catalytic domain
  6. XM_006718657.1XP_006718720.1  ribosomal protein S6 kinase beta-2 isoform X2

    See identical proteins and their annotated locations for XP_006718720.1

    Conserved Domains (1) summary
    cl21453
    Location:1192
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_247207.3 RNA Sequence

    Related
    ENST00000528964.5
  2. XR_247208.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001007071.1: Suppressed sequence

    Description
    NM_001007071.1: This RefSeq was permanently suppressed because because currently there is insufficient support for the transcript, and it is a nonsense-mediated mRNA decay (NMD) candidate.
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