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RPS6KA3 ribosomal protein S6 kinase A3 [ Homo sapiens (human) ]

Gene ID: 6197, updated on 5-Apr-2020

Summary

Official Symbol
RPS6KA3provided by HGNC
Official Full Name
ribosomal protein S6 kinase A3provided by HGNC
Primary source
HGNC:HGNC:10432
See related
Ensembl:ENSG00000177189 MIM:300075
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLS; RSK; HU-3; RSK2; MRX19; ISPK-1; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3
Summary
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 16.2), colon (RPKM 16.0) and 25 other tissues See more
Orthologs

Genomic context

See RPS6KA3 in Genome Data Viewer
Location:
Xp22.12
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (20149911..20267514, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (20168029..20285523, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene EIF1AX antisense RNA 1 Neighboring gene small Cajal body-specific RNA 9 like Neighboring gene eukaryotic translation initiation factor 1A X-linked Neighboring gene RN7SK pseudogene 183 Neighboring gene uncharacterized LOC105373146 Neighboring gene RNA, U6 small nuclear 133, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Coffin-Lowry syndrome
MedGen: C0265252 OMIM: 303600 GeneReviews: Coffin-Lowry Syndrome
Compare labs
Mental retardation, X-linked 19
MedGen: C0796225 OMIM: 300844 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2012-08-09)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2012-08-09)

ClinGen Genome Curation PagePubMed

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ribosomal protein S6 kinase, polypeptide 3 (RPS6KA3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat RSK2 is selectively involved in LTR stimulation by the HIV-1 Tat protein, but constitutively active RSK2 is unable to stimulate the LTR PubMed
tat Interaction of HIV-1 Tat with p90 ribosomal S6 kinase 2 (RSK2) is observed in vivo and in vitro. The critical interacting residues lie within amino acids 36-39 in Tat and 1-360 in RSK2. RSK2 supports HIV-1 Tat transactivation via binding to F38 PubMed
tat Activation of the N-terminal RSK2 kinase activity is enhanced by HIV-1 Tat in a dose-dependent manner. PubMed
tat Phosphorylation of serine 227 in RSK2 is increased by Tat; mutation at position F38 abolishes the Tat-mediated phosphorylation of RSK2. PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
central nervous system development TAS
Traceable Author Statement
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell differentiation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell growth TAS
Traceable Author Statement
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of DNA-templated transcription in response to stress TAS
Traceable Author Statement
more info
PubMed 
regulation of translation in response to stress TAS
Traceable Author Statement
more info
PubMed 
response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ribosomal protein S6 kinase alpha-3
Names
MAP kinase-activated protein kinase 1b
MAPK-activated protein kinase 1b
MAPKAP kinase 1b
MAPKAPK-1b
RSK-2
S6K-alpha-3
epididymis secretory sperm binding protein
insulin-stimulated protein kinase 1
p90-RSK 3
ribosomal S6 kinase 2
ribosomal protein S6 kinase, 90kDa, polypeptide 3
NP_004577.1
XP_005274630.1
XP_005274634.1
XP_006724570.1
XP_011543857.1
XP_011543858.1
XP_011543859.1
XP_011543860.1
XP_011543862.1
XP_011543863.1
XP_011543864.1
XP_011543865.1
XP_016885202.1
XP_016885203.1
XP_016885204.1
XP_016885205.1
XP_016885206.1
XP_016885207.1
XP_016885208.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007488.1 RefSeqGene

    Range
    4724..121722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004586.3NP_004577.1  ribosomal protein S6 kinase alpha-3

    See identical proteins and their annotated locations for NP_004577.1

    Status: REVIEWED

    Source sequence(s)
    AA317826, AA858312, AB102662, AK022869, AL732366, AL807772, AV684171, BC015451, BQ427696, BU618685, CA843287, CA843526, CK905714, U08316, W00439
    Consensus CDS
    CCDS14197.1
    UniProtKB/Swiss-Prot
    P51812
    Related
    ENSP00000368884.3, ENST00000379565.9
    Conserved Domains (2) summary
    cd05582
    Location:72388
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:402740
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    20149911..20267514 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029716.1XP_016885205.1  ribosomal protein S6 kinase alpha-3 isoform X6

    UniProtKB/TrEMBL
    B7ZB17
    Related
    ENSP00000493862.1, ENST00000643402.1
    Conserved Domains (2) summary
    cd05582
    Location:44360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374712
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
  2. XM_017029719.2XP_016885208.1  ribosomal protein S6 kinase alpha-3 isoform X8

    UniProtKB/TrEMBL
    B4DG22
    Conserved Domains (2) summary
    cd05582
    Location:44360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374711
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
  3. XM_017029717.2XP_016885206.1  ribosomal protein S6 kinase alpha-3 isoform X6

    UniProtKB/TrEMBL
    B7ZB17
    Related
    ENSP00000495462.1, ENST00000646610.1
    Conserved Domains (2) summary
    cd05582
    Location:44360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374712
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
  4. XM_011545561.2XP_011543863.1  ribosomal protein S6 kinase alpha-3 isoform X4

    See identical proteins and their annotated locations for XP_011543863.1

    Conserved Domains (4) summary
    smart00220
    Location:40305
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:44366
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:380718
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    pfam00069
    Location:400657
    Pkinase; Protein kinase domain
  5. XM_017029713.1XP_016885202.1  ribosomal protein S6 kinase alpha-3 isoform X6

    UniProtKB/TrEMBL
    B7ZB17
    Related
    ENSP00000494220.1, ENST00000647265.1
    Conserved Domains (2) summary
    cd05582
    Location:44360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374712
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
  6. XM_006724507.3XP_006724570.1  ribosomal protein S6 kinase alpha-3 isoform X8

    See identical proteins and their annotated locations for XP_006724570.1

    UniProtKB/TrEMBL
    B4DG22
    Related
    ENSP00000495974.1, ENST00000644893.1
    Conserved Domains (2) summary
    cd05582
    Location:44360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374711
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
  7. XM_017029715.2XP_016885204.1  ribosomal protein S6 kinase alpha-3 isoform X6

    UniProtKB/TrEMBL
    B7ZB17
    Related
    ENSP00000494769.1, ENST00000642835.1
    Conserved Domains (2) summary
    cd05582
    Location:44360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374712
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
  8. XM_005274573.2XP_005274630.1  ribosomal protein S6 kinase alpha-3 isoform X3

    See identical proteins and their annotated locations for XP_005274630.1

    Conserved Domains (2) summary
    cd05582
    Location:72388
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:402739
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
  9. XM_011545556.1XP_011543858.1  ribosomal protein S6 kinase alpha-3 isoform X2

    Conserved Domains (4) summary
    smart00220
    Location:68333
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:72394
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:408745
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    pfam00069
    Location:427684
    Pkinase; Protein kinase domain
  10. XM_011545555.1XP_011543857.1  ribosomal protein S6 kinase alpha-3 isoform X1

    Conserved Domains (4) summary
    smart00220
    Location:68333
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:72394
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:408737
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    pfam00069
    Location:428685
    Pkinase; Protein kinase domain
  11. XM_011545560.1XP_011543862.1  ribosomal protein S6 kinase alpha-3 isoform X4

    See identical proteins and their annotated locations for XP_011543862.1

    Conserved Domains (4) summary
    smart00220
    Location:40305
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:44366
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:380718
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    pfam00069
    Location:400657
    Pkinase; Protein kinase domain
  12. XM_011545557.2XP_011543859.1  ribosomal protein S6 kinase alpha-3 isoform X4

    See identical proteins and their annotated locations for XP_011543859.1

    Conserved Domains (4) summary
    smart00220
    Location:40305
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:44366
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:380718
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    pfam00069
    Location:400657
    Pkinase; Protein kinase domain
  13. XM_011545558.2XP_011543860.1  ribosomal protein S6 kinase alpha-3 isoform X4

    See identical proteins and their annotated locations for XP_011543860.1

    Conserved Domains (4) summary
    smart00220
    Location:40305
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:44366
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:380718
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    pfam00069
    Location:400657
    Pkinase; Protein kinase domain
  14. XM_011545563.3XP_011543865.1  ribosomal protein S6 kinase alpha-3 isoform X6

    See identical proteins and their annotated locations for XP_011543865.1

    UniProtKB/TrEMBL
    B7ZB17
    Related
    ENSP00000496271.1, ENST00000643085.1
    Conserved Domains (2) summary
    cd05582
    Location:44360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374712
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
  15. XM_017029714.2XP_016885203.1  ribosomal protein S6 kinase alpha-3 isoform X6

    UniProtKB/TrEMBL
    B7ZB17
    Conserved Domains (2) summary
    cd05582
    Location:44360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374712
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
  16. XM_005274577.3XP_005274634.1  ribosomal protein S6 kinase alpha-3 isoform X9

    See identical proteins and their annotated locations for XP_005274634.1

    Conserved Domains (2) summary
    cd05582
    Location:43359
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:373710
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
  17. XM_017029718.2XP_016885207.1  ribosomal protein S6 kinase alpha-3 isoform X7

    Related
    ENSP00000407655.2, ENST00000457145.6
    Conserved Domains (4) summary
    smart00220
    Location:39298
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:43359
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:373711
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    pfam00069
    Location:393650
    Pkinase; Protein kinase domain
  18. XM_011545562.2XP_011543864.1  ribosomal protein S6 kinase alpha-3 isoform X5

    Conserved Domains (4) summary
    smart00220
    Location:39304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:43365
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:379717
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    pfam00069
    Location:399656
    Pkinase; Protein kinase domain
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