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Klf14 Kruppel-like transcription factor 14 [ Mus musculus (house mouse) ]

Gene ID: 619665, updated on 8-Feb-2024

Summary

Official Symbol
Klf14provided by MGI
Official Full Name
Kruppel-like transcription factor 14provided by MGI
Primary source
MGI:MGI:3577024
See related
Ensembl:ENSMUSG00000073209 AllianceGenome:MGI:3577024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BTEB5; 5330411L03Rik
Summary
Enables chromatin binding activity. Acts upstream of or within positive regulation of sphingolipid mediated signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including brain; gut; male reproductive gland or organ; respiratory system; and skin. Orthologous to human KLF14 (Kruppel like factor 14). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Klf14 in Genome Data Viewer
Location:
6 A3.3; 6 12.54 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30932956..30935925, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30956021..30958990, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene coatomer protein complex, subunit gamma 2 Neighboring gene RIKEN cDNA 4930412F09 gene Neighboring gene predicted gene, 38781 Neighboring gene testis specific gene A13 Neighboring gene STARR-seq mESC enhancer starr_15475 Neighboring gene predicted gene, 40359 Neighboring gene microRNA 29a

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Krueppel-like factor 14
Names
Kruppel-like factor 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135093.1NP_001128565.1  Krueppel-like factor 14

    See identical proteins and their annotated locations for NP_001128565.1

    Status: VALIDATED

    Source sequence(s)
    AC121800
    Consensus CDS
    CCDS51744.1
    UniProtKB/Swiss-Prot
    Q19A41
    Related
    ENSMUSP00000099122.4, ENSMUST00000101589.5
    Conserved Domains (3) summary
    COG5048
    Location:198283
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:200219
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:241266
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    30932956..30935925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)