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RPS5 ribosomal protein S5 [ Homo sapiens (human) ]

Gene ID: 6193, updated on 7-Jun-2020

Summary

Official Symbol
RPS5provided by HGNC
Official Full Name
ribosomal protein S5provided by HGNC
Primary source
HGNC:HGNC:10426
See related
Ensembl:ENSG00000083845 MIM:603630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S5
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 988.2), bone marrow (RPKM 469.7) and 25 other tissues See more
Orthologs

Genomic context

See RPS5 in Genome Data Viewer
Location:
19q13.43
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (58387269..58394804)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58898636..58906171)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 837 Neighboring gene uncharacterized LOC105372484 Neighboring gene Sharpr-MPRA regulatory region 7872 Neighboring gene microRNA 4754 Neighboring gene microRNA 10394 Neighboring gene ring finger protein 225 Neighboring gene long intergenic non-protein coding RNA 2560

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with RPS5 as demonstrated by proximity dependent biotinylation proteomics PubMed
Rev rev HIV-1 Rev interacting protein, ribosomal protein S5 (RPS5), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome HDA PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
regulation of translational fidelity IGI
Inferred from Genetic Interaction
more info
PubMed 
ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation IC
Inferred by Curator
more info
PubMed 
translation IGI
Inferred from Genetic Interaction
more info
PubMed 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation IC
Inferred by Curator
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic small ribosomal subunit HDA PubMed 
cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
membrane HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
40S ribosomal protein S5
Names
small ribosomal subunit protein uS7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009.4NP_001000.2  40S ribosomal protein S5

    See identical proteins and their annotated locations for NP_001000.2

    Status: REVIEWED

    Source sequence(s)
    BC015405, BG687415
    Consensus CDS
    CCDS12978.1
    UniProtKB/Swiss-Prot
    P46782
    UniProtKB/TrEMBL
    A0A024R4Q8
    Related
    ENSP00000196551.3, ENST00000196551.8
    Conserved Domains (1) summary
    cd14867
    Location:18204
    uS7_Eukaryote; Eukaryota homolog of Ribosomal Protein S7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    58387269..58394804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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