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RPS4Y1 ribosomal protein S4 Y-linked 1 [ Homo sapiens (human) ]

Gene ID: 6192, updated on 5-Apr-2020

Summary

Official Symbol
RPS4Y1provided by HGNC
Official Full Name
ribosomal protein S4 Y-linked 1provided by HGNC
Primary source
HGNC:HGNC:10425
See related
Ensembl:ENSG00000129824 MIM:470000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S4; RPS4Y
Summary
Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, X-linked (RPS4X). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Broad expression in prostate (RPKM 119.8), small intestine (RPKM 81.8) and 20 other tissues See more
Orthologs

Genomic context

See RPS4Y1 in Genome Data Viewer
Location:
Yp11.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (2841602..2867268)
105 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (2709623..2734997)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene SRY promoter region Neighboring gene ribonuclease H2 subunit C pseudogene 1 Neighboring gene TOMM22 pseudogene 2 Neighboring gene heat shock transcription factor Y-linked 3, pseudogene Neighboring gene nucleosome assembly protein 1 like 1 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5070, MGC119100

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA binding IEA
Inferred from Electronic Annotation
more info
 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
multicellular organism development IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 
membrane HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
polysome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
40S ribosomal protein S4, Y isoform 1
Names
40S ribosomal protein S4, Y
ribosomal protein S4, Y-linked
ribosomal protein S4Y
small ribosomal subunit protein eS4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008.4NP_000999.1  40S ribosomal protein S4, Y isoform 1

    See identical proteins and their annotated locations for NP_000999.1

    Status: REVIEWED

    Source sequence(s)
    AC006040, AI167386, BC010286, BF242790
    Consensus CDS
    CCDS14773.1
    UniProtKB/Swiss-Prot
    P22090
    Related
    ENSP00000250784.7, ENST00000250784.13
    Conserved Domains (6) summary
    PLN00036
    Location:1260
    PLN00036; 40S ribosomal protein S4; Provisional
    cd00165
    Location:44112
    S4; S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized ...
    cd06087
    Location:175229
    KOW_RPS4; KOW motif of Ribosomal Protein S4 (RPS4)
    pfam00900
    Location:95169
    Ribosomal_S4e; Ribosomal family S4e
    pfam08071
    Location:339
    RS4NT; RS4NT (NUC023) domain
    pfam16121
    Location:212259
    40S_S4_C; 40S ribosomal protein S4 C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

    Range
    2841602..2867268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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