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RPN1 ribophorin I [ Homo sapiens (human) ]

Gene ID: 6184, updated on 9-Jun-2020

Summary

Official Symbol
RPN1provided by HGNC
Official Full Name
ribophorin Iprovided by HGNC
Primary source
HGNC:HGNC:10381
See related
Ensembl:ENSG00000163902 MIM:180470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OST1; RBPH1
Summary
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 116.8), placenta (RPKM 79.5) and 25 other tissues See more
Orthologs

Genomic context

See RPN1 in Genome Data Viewer
Location:
3q21.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (128619969..128650818, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (128338813..128369719, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1565 Neighboring gene Sharpr-MPRA regulatory region 3129 Neighboring gene POU class 5 homeobox 1 pseudogene 6 Neighboring gene RAB7A, member RAS oncogene family Neighboring gene microtubule affinity regulating kinase 2 pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genetic variation associated with circulating monocyte count in the eMERGE Network.
NHGRI GWA Catalog
Multiple loci are associated with white blood cell phenotypes.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribophorin I (RPN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribophorin I (RPN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ribophorin I (RPN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribophorin I (RPN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of ribophorin I (RPN1) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686B16177

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
protein N-linked glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein N-linked glycosylation via asparagine IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein N-linked glycosylation via asparagine TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
melanosome IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oligosaccharyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
oligosaccharyltransferase complex TAS
Traceable Author Statement
more info
PubMed 
rough endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Names
RPN-I
dolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunit
oligosaccharyltransferase 1 homolog
oligosaccharyltransferase complex subunit (non-catalytic)
ribophorin-1
NP_002941.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002950.4NP_002941.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor

    See identical proteins and their annotated locations for NP_002941.1

    Status: REVIEWED

    Source sequence(s)
    AC079945, BC010839
    Consensus CDS
    CCDS3051.1
    UniProtKB/Swiss-Prot
    P04843
    Related
    ENSP00000296255.3, ENST00000296255.8
    Conserved Domains (2) summary
    pfam04597
    Location:33457
    Ribophorin_I; Ribophorin I
    pfam10482
    Location:480596
    CtIP_N; tumor-suppressor protein CtIP N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    128619969..128650818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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