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RPN1 ribophorin I [ Homo sapiens (human) ]

Gene ID: 6184, updated on 3-Nov-2024

Summary

Official Symbol
RPN1provided by HGNC
Official Full Name
ribophorin Iprovided by HGNC
Primary source
HGNC:HGNC:10381
See related
Ensembl:ENSG00000163902 MIM:180470; AllianceGenome:HGNC:10381
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OST1; RBPH1
Summary
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 116.8), placenta (RPKM 79.5) and 25 other tissues See more
Orthologs
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Genomic context

See RPN1 in Genome Data Viewer
Location:
3q21.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (128619969..128650818, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (131361936..131392788, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (128338812..128369661, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1565 Neighboring gene uncharacterized LOC124909430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:128309380-128309880 Neighboring gene Sharpr-MPRA regulatory region 3129 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:128321651-128322150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20484 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:128336746-128337257 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:128363771-128364272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:128364273-128364772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20487 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20489 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:128384140-128385070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20490 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:128399363-128400055 Neighboring gene POU class 5 homeobox 1 pseudogene 6 Neighboring gene small nucleolar RNA SNORA24

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic variation associated with circulating monocyte count in the eMERGE Network.
EBI GWAS Catalog
Multiple loci are associated with white blood cell phenotypes.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribophorin I (RPN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribophorin I (RPN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ribophorin I (RPN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribophorin I (RPN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of ribophorin I (RPN1) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp686B16177

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
part_of oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of oligosaccharyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of oligosaccharyltransferase complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of oligosaccharyltransferase complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in rough endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Names
RPN-I
dolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunit
oligosaccharyltransferase 1 homolog
oligosaccharyltransferase complex subunit (non-catalytic)
ribophorin-1
NP_002941.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002950.4NP_002941.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor

    See identical proteins and their annotated locations for NP_002941.1

    Status: REVIEWED

    Source sequence(s)
    AC079945, BC010839
    Consensus CDS
    CCDS3051.1
    UniProtKB/Swiss-Prot
    B2R5Z0, D3DNB6, P04843, Q68DT1
    UniProtKB/TrEMBL
    Q53EP4
    Related
    ENSP00000296255.3, ENST00000296255.8
    Conserved Domains (1) summary
    pfam04597
    Location:32457
    Ribophorin_I; Ribophorin I

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    128619969..128650818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    131361936..131392788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)