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BDNF brain derived neurotrophic factor [ Bos taurus (domestic cattle) ]

Gene ID: 617701, updated on 5-Sep-2025
Official Symbol
BDNFprovided by VGNC
Official Full Name
brain derived neurotrophic factorprovided by VGNC
Primary source
VGNC:VGNC:26461
See related
BGD:BT12389; EnsemblRapid:ENSBTAG00070034226
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See BDNF in Genome Data Viewer
Location:
chromosome: 15
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (58382886..58445297, complement)

Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing G protein-coupled receptor 4 Neighboring gene lin-7 homolog C, crumbs cell polarity complex component Neighboring gene uncharacterized LOC132342349 Neighboring gene kinesin family member 18A Neighboring gene transfer RNA cysteine (anticodon ACA)

Genomic Sequence:
NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. The gene encoding bovine brain-derived neurotrophic factor (BDNF). Arab SF, et al. Gene, 1997 Jan 31. PMID 9034318
  2. The expression and putative role of brain-derived neurotrophic factor and its receptor in bovine sperm. Li C, et al. Theriogenology, 2012 Feb. PMID 22015157
  3. Expression of brain-derived neurotrophic factor and tropomyosin-related kinase-B in a bovine jejunal nodular ganglioneuroblastoma. Ulrich R, et al. Vet Pathol, 2008 May. PMID 18487493
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These observations provided evidence that brain-derived naeurotrophic factor(BDNF) and its receptor (BDNF receptor) secreted by bovine sperm was important in regulation of insulin and leptin.
    Title: The expression and putative role of brain-derived neurotrophic factor and its receptor in bovine sperm.
  2. Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic pathway involving BDNF.
    Title: Expression of brain-derived neurotrophic factor and tropomyosin-related kinase-B in a bovine jejunal nodular ganglioneuroblastoma.
Submit: New GeneRIF Correction

Markers

Homology

Clone Names

  • MGC133995

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nerve growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in memory IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nerve development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nerve growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron projection morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peripheral nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of collateral sprouting IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
neurotrophic factor BDNF precursor form
Names
proBDNF

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001046607.2 → NP_001040072.1  neurotrophic factor BDNF precursor form precursor

    See identical proteins and their annotated locations for NP_001040072.1

    Status: PROVISIONAL

    Source sequence(s)
    BC109860
    UniProtKB/Swiss-Prot
    Q32KY2, Q95106
    UniProtKB/TrEMBL
    A0AAA9SHE4
    Related
    ENSBTAP00070046919.1, ENSBTAT00070077030.1
    Conserved Domains (1) summary
    smart00140
    Location:136 → 243
    NGF; Nerve growth factor (NGF or beta-NGF)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    58382886..58445297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005216334.5 → XP_005216391.1  neurotrophic factor BDNF precursor form isoform X1

    See identical proteins and their annotated locations for XP_005216391.1

    UniProtKB/TrEMBL
    A0AAA9SHE4, A0AAA9T573
    Related
    ENSBTAP00070046960.1, ENSBTAT00070077089.1
    Conserved Domains (1) summary
    smart00140
    Location:144 → 251
    NGF; Nerve growth factor (NGF or beta-NGF)

  2. XM_059874987.1 → XP_059730970.1  neurotrophic factor BDNF precursor form isoform X2

    UniProtKB/Swiss-Prot
    Q32KY2, Q95106
    UniProtKB/TrEMBL
    A0AAA9SHE4

  3. XM_005216335.5 → XP_005216392.1  neurotrophic factor BDNF precursor form isoform X2

    See identical proteins and their annotated locations for XP_005216392.1

    UniProtKB/Swiss-Prot
    Q32KY2, Q95106
    UniProtKB/TrEMBL
    A0AAA9SHE4
    Related
    ENSBTAP00070046930.1, ENSBTAT00070077046.1
    Conserved Domains (1) summary
    smart00140
    Location:136 → 243
    NGF; Nerve growth factor (NGF or beta-NGF)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95106.2 GenPept UniProtKB/Swiss-Prot:Q95106

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.