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RPLP1 ribosomal protein lateral stalk subunit P1 [ Homo sapiens (human) ]

Gene ID: 6176, updated on 1-Aug-2020

Summary

Official Symbol
RPLP1provided by HGNC
Official Full Name
ribosomal protein lateral stalk subunit P1provided by HGNC
Primary source
HGNC:HGNC:10372
See related
Ensembl:ENSG00000137818 MIM:180520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P1; LP1; RPP1
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 1137.8), ovary (RPKM 979.2) and 25 other tissues See more
Orthologs

Genomic context

See RPLP1 in Genome Data Viewer
Location:
15q23
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (69452818..69456205)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (69745159..69747884)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene progestin and adipoQ receptor family member 5 Neighboring gene uncharacterized LOC145694 Neighboring gene fumarylacetoacetate hydrolase domain containing 1 pseudogene Neighboring gene kinesin family member 23 Neighboring gene uncharacterized LOC105370876 Neighboring gene Sharpr-MPRA regulatory region 2 Neighboring gene downregulated RNA in cancer, inhibitor of cell invasion and migration

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
NHGRI GWA Catalog
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5215, FLJ27448

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoprotein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational elongation IEA
Inferred from Electronic Annotation
more info
 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion HDA PubMed 

General protein information

Preferred Names
60S acidic ribosomal protein P1
Names
acidic ribosomal phosphoprotein P1
large ribosomal subunit protein P1
ribosomal protein, large, P1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003.3NP_000994.1  60S acidic ribosomal protein P1 isoform 1

    See identical proteins and their annotated locations for NP_000994.1

    Status: REVIEWED

    Description
    Transcript Variant: This predominant variant (1) is the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC027237
    Consensus CDS
    CCDS10233.1
    UniProtKB/Swiss-Prot
    P05386
    UniProtKB/TrEMBL
    A0A024R608
    Related
    ENSP00000346037.5, ENST00000260379.11
    Conserved Domains (1) summary
    cd05831
    Location:663
    Ribosomal_P1; Ribosomal protein P1. This subfamily represents the eukaryotic large ribosomal protein P1. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P1 is located in the L12 stalk, with proteins ...
  2. NM_213725.2NP_998890.1  60S acidic ribosomal protein P1 isoform 2

    See identical proteins and their annotated locations for NP_998890.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2) when compared to isoform 1.
    Source sequence(s)
    AC027237, BM745938, M17886
    Consensus CDS
    CCDS10234.1
    UniProtKB/Swiss-Prot
    P05386
    Related
    ENSP00000350437.5, ENST00000357790.5
    Conserved Domains (1) summary
    cl21508
    Location:688
    Ribosomal_P1_P2_L12p; Ribosomal protein P1, P2, and L12p. Ribosomal proteins P1 and P2 are the eukaryotic proteins that are functionally equivalent to bacterial L7/L12. L12p is the archaeal homolog. Unlike other ribosomal proteins, the archaeal L12p and eukaryotic P1 and P2 ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    69452818..69456205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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