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RPLP0 ribosomal protein lateral stalk subunit P0 [ Homo sapiens (human) ]

Gene ID: 6175, updated on 5-Jan-2020

Summary

Official Symbol
RPLP0provided by HGNC
Official Full Name
ribosomal protein lateral stalk subunit P0provided by HGNC
Primary source
HGNC:HGNC:10371
See related
Ensembl:ENSG00000089157 MIM:180510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P0; LP0; L10E; RPP0; PRLP0
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 1127.2), bone marrow (RPKM 877.2) and 25 other tissues See more
Orthologs

Genomic context

See RPLP0 in Genome Data Viewer
Location:
12q24.23
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (120196699..120201211, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120634502..120639014, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RAB35, member RAS oncogene family Neighboring gene GCN1 activator of EIF2AK4 Neighboring gene microRNA 4498 Neighboring gene PXN antisense RNA 1 Neighboring gene paxillin Neighboring gene ribosomal protein S20 pseudogene 31

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify the P0 protein of 60S ribosomal protein large subunit (RPLP0), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify the P0 protein of 60S ribosomal protein large subunit (RPLP0), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify the P0 protein of 60S ribosomal protein large subunit (RPLP0), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify the P0 protein of 60S ribosomal protein large subunit (RPLP0), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of ribosomal protein P0 (RPLP0) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC88175, MGC111226

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
large ribosomal subunit rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-12-mediated signaling pathway TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
membrane HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
postsynapse EXP
Inferred from Experiment
more info
PubMed 
postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density EXP
Inferred from Experiment
more info
PubMed 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
60S acidic ribosomal protein P0
Names
60S ribosomal protein L10E
acidic ribosomal phosphoprotein P0
large ribosomal subunit protein uL10
neutral ribosomal phosphoprotein P0
ribosomal protein, large, P0

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002.4NP_000993.1  60S acidic ribosomal protein P0

    See identical proteins and their annotated locations for NP_000993.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant transcript. It has a different 5' UTR than variant 2. They encode the same protein.
    Source sequence(s)
    AC004263, BC000087, BC019014, BF131912
    Consensus CDS
    CCDS9193.1
    UniProtKB/Swiss-Prot
    P05388
    UniProtKB/TrEMBL
    A0A024RBS2
    Related
    ENSP00000376299.4, ENST00000392514.9
    Conserved Domains (1) summary
    PTZ00135
    Location:1317
    PTZ00135; 60S acidic ribosomal protein P0; Provisional
  2. NM_053275.3NP_444505.1  60S acidic ribosomal protein P0

    See identical proteins and their annotated locations for NP_444505.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a different 5' UTR than variant 1. They encode the same protein.
    Source sequence(s)
    BC003655, BC019014, BF131912
    Consensus CDS
    CCDS9193.1
    UniProtKB/Swiss-Prot
    P05388
    UniProtKB/TrEMBL
    A0A024RBS2
    Related
    ENSP00000339027.3, ENST00000228306.8
    Conserved Domains (1) summary
    PTZ00135
    Location:1317
    PTZ00135; 60S acidic ribosomal protein P0; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    120196699..120201211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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