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RPL41 ribosomal protein L41 [ Homo sapiens (human) ]

Gene ID: 6171, updated on 29-Mar-2023

Summary

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Official Symbol
RPL41provided by HGNC
Official Full Name
ribosomal protein L41provided by HGNC
Primary source
HGNC:HGNC:10354
See related
Ensembl:ENSG00000229117 MIM:613315; AllianceGenome:HGNC:10354
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L41; eL41
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with the yeast ribosomal protein YL41, belongs to the L41E family of ribosomal proteins. It is located in the cytoplasm. The protein can interact with the beta subunit of protein kinase CKII and can stimulate the phosphorylation of DNA topoisomerase II-alpha by CKII. Two alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 1672.2), colon (RPKM 1110.0) and 25 other tissues See more
Orthologs
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Genomic context

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See RPL41 in Genome Data Viewer
Location:
12q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (56116633..56117967)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (56084231..56085565)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56510417..56511751)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369782 Neighboring gene proliferation-associated 2G4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:56514939-56515936 Neighboring gene zinc finger CCCH-type containing 10 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56521723-56522384 Neighboring gene extended synaptotagmin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RPL41, a small ribosomal peptide deregulated in tumors, is essential for mitosis and centrosome integrity. Wang S, et al. Neoplasia, 2010 Mar. PMID 20234822, Free PMC Article
  2. Genomic structure of the human ribosomal protein L41 gene. Go H, et al. Biochem Mol Biol Int, 1998 Dec. PMID 9891856
  3. Characterization by cDNA cloning of the mRNA of a highly basic human protein homologous to the yeast ribosomal protein YL41. Klaudiny J, et al. Biochem Biophys Res Commun, 1992 Sep 16. PMID 1326959
  4. RPL41 sensitizes retinoblastoma cells to chemotherapeutic drugs via ATF4 degradation. Geng W, et al. J Cell Physiol, 2021 Mar. PMID 32783256
  5. Ribosomal protein RPL41 induces rapid degradation of ATF4, a transcription factor critical for tumour cell survival in stress. Wang A, et al. J Pathol, 2011 Oct. PMID 21706477

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RPL41 sensitizes retinoblastoma cells to chemotherapeutic drugs via ATF4 degradation.
    Title: RPL41 sensitizes retinoblastoma cells to chemotherapeutic drugs via ATF4 degradation.
  2. Differential gene expression analysis demonstrated significant upregulation of PDZK1IP1, EEF1A2 and RPL41 (ENSG00000279483) genes in the intrahepatic cholangiocarcinoma samples when compared with the matched paratumor samples.
    Title: Overexpression of PDZK1IP1, EEF1A2 and RPL41 genes in intrahepatic cholangiocarcinoma.
  3. we show that RPL41 induces ATF4 phosphorylation and rapid degradation in the proteasome
    Title: Ribosomal protein RPL41 induces rapid degradation of ATF4, a transcription factor critical for tumour cell survival in stress.
  4. RPL41 down-regulation is associated with breast neoplasms.
    Title: RPL41, a small ribosomal peptide deregulated in tumors, is essential for mitosis and centrosome integrity.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit HDA PubMed 
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
  
located_in polysomal ribosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
60S ribosomal protein L41
Names
HG12 protein
homologue of yeast ribosomal protein YL41
large ribosomal subunit protein eL41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035267.2 → NP_001030344.1  60S ribosomal protein L41

    See identical proteins and their annotated locations for NP_001030344.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is the longer transcript, containing a unique segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC034102, BC064907, BC082759, BF673574
    Consensus CDS
    CCDS44919.1
    UniProtKB/Swiss-Prot
    P28751, P62945
    UniProtKB/TrEMBL
    A0A024RB15
    Related
    ENSP00000449026.1, ENST00000546591.6
    Conserved Domains (1) summary
    pfam05162
    Location:1 → 24
    Ribosomal_L41; Ribosomal protein L41

  2. NM_021104.2 → NP_066927.1  60S ribosomal protein L41

    See identical proteins and their annotated locations for NP_066927.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC034102, Z12962
    Consensus CDS
    CCDS44919.1
    UniProtKB/Swiss-Prot
    P28751, P62945
    UniProtKB/TrEMBL
    A0A024RB15
    Related
    ENSP00000420821.3, ENST00000501597.3
    Conserved Domains (1) summary
    pfam05162
    Location:1 → 24
    Ribosomal_L41; Ribosomal protein L41

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    56116633..56117967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    56084231..56085565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62945.1 GenPept UniProtKB/Swiss-Prot:P62945

Gene LinkOut

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