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RPL41 ribosomal protein L41 [ Homo sapiens (human) ]

Gene ID: 6171, updated on 7-Jun-2020

Summary

Official Symbol
RPL41provided by HGNC
Official Full Name
ribosomal protein L41provided by HGNC
Primary source
HGNC:HGNC:10354
See related
Ensembl:ENSG00000229117 MIM:613315
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L41
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with the yeast ribosomal protein YL41, belongs to the L41E family of ribosomal proteins. It is located in the cytoplasm. The protein can interact with the beta subunit of protein kinase CKII and can stimulate the phosphorylation of DNA topoisomerase II-alpha by CKII. Two alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 1672.2), colon (RPKM 1110.0) and 25 other tissues See more
Orthologs

Genomic context

See RPL41 in Genome Data Viewer
Location:
12q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (56116633..56117967)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56510374..56511616)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene erb-b2 receptor tyrosine kinase 3 Neighboring gene uncharacterized LOC105369782 Neighboring gene proliferation-associated 2G4 Neighboring gene zinc finger CCCH-type containing 10 Neighboring gene extended synaptotagmin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding TAS
Traceable Author Statement
more info
PubMed 
mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
cytoplasmic translation IDA
Inferred from Direct Assay
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
polysomal ribosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
60S ribosomal protein L41
Names
HG12 protein
homologue of yeast ribosomal protein YL41
large ribosomal subunit protein eL41

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035267.2NP_001030344.1  60S ribosomal protein L41

    See identical proteins and their annotated locations for NP_001030344.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is the longer transcript, containing a unique segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC034102, BC064907, BC082759, BF673574
    Consensus CDS
    CCDS44919.1
    UniProtKB/Swiss-Prot
    P62945
    UniProtKB/TrEMBL
    A0A024RB15
    Related
    ENSP00000449026.1, ENST00000546591.6
    Conserved Domains (1) summary
    pfam05162
    Location:124
    Ribosomal_L41; Ribosomal protein L41
  2. NM_021104.2NP_066927.1  60S ribosomal protein L41

    See identical proteins and their annotated locations for NP_066927.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC034102, Z12962
    Consensus CDS
    CCDS44919.1
    UniProtKB/Swiss-Prot
    P62945
    UniProtKB/TrEMBL
    A0A024RB15
    Related
    ENSP00000420821.3, ENST00000501597.3
    Conserved Domains (1) summary
    pfam05162
    Location:124
    Ribosomal_L41; Ribosomal protein L41

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    56116633..56117967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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