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RPL35A ribosomal protein L35a [ Homo sapiens (human) ]

Gene ID: 6165, updated on 26-Nov-2021

Summary

Official Symbol
RPL35Aprovided by HGNC
Official Full Name
ribosomal protein L35aprovided by HGNC
Primary source
HGNC:HGNC:10345
See related
Ensembl:ENSG00000182899 MIM:180468
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DBA5; L35A; eL33
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L35AE family of ribosomal proteins. It is located in the cytoplasm. The rat protein has been shown to bind to both initiator and elongator tRNAs, and thus, it is located at the P site, or P and A sites, of the ribosome. Although this gene was originally mapped to chromosome 18, it has been established that it is located at 3q29-qter. Alternative splicing results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Oct 2015]
Expression
Ubiquitous expression in ovary (RPKM 893.9), bone marrow (RPKM 452.8) and 25 other tissues See more
Orthologs
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Genomic context

See RPL35A in Genome Data Viewer
Location:
3q29
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (197950190..197956610)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (197677061..197683481)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NUP98-IQCG recombination region Neighboring gene RNA, U6 small nuclear 858, pseudogene Neighboring gene IQ motif containing G Neighboring gene leishmanolysin like peptidase Neighboring gene RNA, U6 small nuclear 621, pseudogene Neighboring gene LMLN antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, ribosomal protein L35a (RPL35A), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
Tat tat Expression of HIV-1 Tat downregulates the abundance of ribosomal protein L35a (RPL35A) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of ribosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytoplasmic translation IC
Inferred by Curator
more info
PubMed 
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
60S ribosomal protein L35a
Names
cell growth-inhibiting gene 33 protein
large ribosomal subunit protein eL33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011743.1 RefSeqGene

    Range
    5010..11430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1129

mRNA and Protein(s)

  1. NM_000996.4NP_000987.2  60S ribosomal protein L35a

    See identical proteins and their annotated locations for NP_000987.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AW575227, BC010949, BM972808
    Consensus CDS
    CCDS33930.1
    UniProtKB/Swiss-Prot
    P18077
    Related
    ENSP00000495672.1, ENST00000647248.2
    Conserved Domains (1) summary
    pfam01247
    Location:5103
    Ribosomal_L35Ae; Ribosomal protein L35Ae
  2. NM_001316311.2NP_001303240.1  60S ribosomal protein L35a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC135893, BC017093
    Consensus CDS
    CCDS33930.1
    UniProtKB/Swiss-Prot
    P18077
    Related
    ENSP00000393393.1, ENST00000448864.6
    Conserved Domains (1) summary
    pfam01247
    Location:5103
    Ribosomal_L35Ae; Ribosomal protein L35Ae

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    197950190..197956610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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